Bone marrow CX3CR1(+) mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice
SCIE
SCOPUS
- Title
- Bone marrow CX3CR1(+) mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice
- Authors
- Lee, Seungwon; Kim, Hyekang; You, Gihoon; Kim, Young-Min; Lee, Seunghun; Viet-Hoan Le; Kwon, Ohseop; Im, Sin-Hyeog; Kim, You-Me; Kim, Kwang Soon; Sung, Young Chul; Kim, Ki Hean; Surh, Charles D.; Park, Yunji; Lee, Seung-Woo
- Date Issued
- 2019-10
- Publisher
- AMER SOC HEMATOLOGY
- Abstract
- The microbiota regulate hematopoiesis in the bone marrow (BM); however, the detailed mechanisms remain largely unknown. In this study, we explored how microbiota-derived molecules (MDMs) were transferred to the BM and sensed by the local immune cells to control hematopoiesis under steady-state conditions. We reveal that MDMs, including bacterial DNA (bDNA), reach the BM via systemic blood circulation and are captured by CX3CR1(+) mononuclear cells (MNCs). CX3CR1(+) MNCs sense MDMs via endolysosomal Toll-like receptors (TLRs) to produce inflammatory cytokines, which control the basal expansion of hematopoietic progenitors, but not hematopoietic stem cells, and their differentiation potential toward myeloid lineages. CX3CR1(+) MNCs colocate with hematopoietic progenitors at the perivascular region, and the depletion of CX3CR1(+) MNCs impedes bDNA influx into the BM. Moreover, the abrogation of TLR pathways in CX3CR1(+) MNCs abolished the microbiota effect on hematopoiesis. These studies demonstrate that systemic MDMs control BM hematopoiesis by producing CX3CR1(+) MNC-mediated cytokines in the steady-state.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/100139
- DOI
- 10.1182/blood.2019000495
- ISSN
- 0006-4971
- Article Type
- Article
- Citation
- BLOOD, vol. 134, no. 16, page. 1312 - 1322, 2019-10
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