Biodegradable Microneedle Patch Delivering Antigenic Peptide-Hyaluronate Conjugate for Cancer Immunotherapy
SCIE
SCOPUS
- Title
- Biodegradable Microneedle Patch Delivering Antigenic Peptide-Hyaluronate Conjugate for Cancer Immunotherapy
- Authors
- Kim, Hyemin; Seong, Keum-Yong; Lee, Jung Ho; Park, Wonchan; Yang, Seung Yun; Hahn, Sei Kwang
- Date Issued
- 2019-10
- Publisher
- AMER CHEMICAL SOC
- Abstract
- Antigenic peptide-delivery systems have been extensively investigated to harness the immune system for cancer therapy. Cytotoxic T-cell epitope peptide can induce an antigen-specific CD8(+) T-cell response, which subsequently inhibits the growth of antigen-bearing tumors. However, there are only a few facile tailored delivery systems of antigenic peptide for effective cancer immunotherapy. Here, we developed a biodegradable microneedle patch delivering a hyaluronate (HA)-antigenic peptide conjugate for prophylactic cancer immunotherapy. Cytotoxic T-cell epitope peptide (SIINFEKL) was conjugated to HA, which was loaded into a biodegradable HA microneedle (MN) patch to efficiently deliver an antigen to the immune system in the skin. HA could act as a transdermal vaccine carrier eliciting strong immune responses by the efficient stimulation of immunocompetent cells. The HASIINFEKL conjugates loaded into biodegradable MNs were localized near the MN administration site, exhibiting long-term residence for more than 24 h post-administration. Remarkably, a single transdermal vaccination with the MN patch containing HA-SIINFEKL conjugates resulted in a statistically significant inhibition of tumor growth in B16 melanoma model mice by enhancing antigen-specific cytotoxic T-cell responses.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/100141
- DOI
- 10.1021/acsbiomaterials.9b00961
- ISSN
- 2373-9878
- Article Type
- Article
- Citation
- ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 5, no. 10, page. 5150 - 5158, 2019-10
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