DC Field | Value | Language |
---|---|---|
dc.contributor.author | PARK, SEUNG YEOL | - |
dc.contributor.author | YANG, JIA-SHU | - |
dc.contributor.author | HSU, JIA-WEI | - |
dc.contributor.author | LI, JIAN | - |
dc.contributor.author | OLDHAM, WILLIAM M. | - |
dc.contributor.author | BEZNOUSSENKO, GALINA V. | - |
dc.contributor.author | Mironov, Alexander A. | - |
dc.contributor.author | Loscalzo, Joseph | - |
dc.contributor.author | HSU, Victor W. | - |
dc.date.accessioned | 2019-12-05T01:50:03Z | - |
dc.date.available | 2019-12-05T01:50:03Z | - |
dc.date.created | 2019-12-04 | - |
dc.date.issued | 2018-09 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/100356 | - |
dc.description.abstract | Starvation poses a fundamental challenge to cell survival. Whereas the role of autophagy in promoting energy homeostasis in this setting has been extensively characterized1, other mechanisms are less well understood. Here we reveal that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) inhibits coat protein I (COPI) transport by targeting a GTPase-activating protein (GAP) towards ADP-ribosylation factor 1 (ARF1) to suppress COPI vesicle fission. GAPDH inhibits multiple other transport pathways, also by targeting ARF GAPs. Further characterization suggests that this broad inhibition is activated by the cell during starvation to reduce energy consumption. These findings reveal a remarkable level of coordination among the intracellular transport pathways that underlies a critical mechanism of cellular energy homeostasis. | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Nature | - |
dc.title | GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41586-018-0475-6 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Nature, v.561, no.7722, pp.263 - 267 | - |
dc.identifier.wosid | 000444437900048 | - |
dc.citation.endPage | 267 | - |
dc.citation.number | 7722 | - |
dc.citation.startPage | 263 | - |
dc.citation.title | Nature | - |
dc.citation.volume | 561 | - |
dc.contributor.affiliatedAuthor | PARK, SEUNG YEOL | - |
dc.identifier.scopusid | 2-s2.0-85053176455 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | GOLGI | - |
dc.subject.keywordPlus | COAT | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordPlus | VESICLE FORMATION | - |
dc.subject.keywordPlus | ARFGAP1 PROMOTES | - |
dc.subject.keywordPlus | COPI | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | TRANSPORT | - |
dc.subject.keywordPlus | MEMBRANE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.