DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo K.D. | - |
dc.contributor.author | Shin S. | - |
dc.contributor.author | Yoo H.Y. | - |
dc.contributor.author | Cao J. | - |
dc.contributor.author | Lee S. | - |
dc.contributor.author | Yoo J.-W. | - |
dc.contributor.author | Kim D.S. | - |
dc.contributor.author | Hwang D.S. | - |
dc.date.accessioned | 2020-02-18T01:50:04Z | - |
dc.date.available | 2020-02-18T01:50:04Z | - |
dc.date.created | 2020-01-21 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.issn | 1525-7797 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/100977 | - |
dc.description.abstract | Low interfacial energy, an intrinsic property of complex coacervate, enables the complex coacervate to easily encapsulate desired cargo substances, making it widely used in encapsulation applications. Despite this advantage, the low interfacial energy of the complex coacervate makes it unstable against mechanical mixing, and changes in pH and salt concentration. Hence, a chemical cross-linker is usually added to enhance the stability of the complex coacervate at the expense of sacrificing all intrinsic properties of the coacervate, including phase transition of the coacervate from liquid to solid. In this study, we observed an abrupt increase in the interfacial energy of the coacervate phase in mineral oil. By controlling the interfacial energy of the coacervate phase using a microfluidic device, we successfully created double engulfed PEG-diacrylate (PEGDA) coacervate microparticles, named DEPOT, in which the coacervate is engulfed in a cross-linked PEGDA shell. The engulfed coacervate remained as a liquid phase, retained its original low interfacial energy property to encapsulate the desired cargo substances, and infiltrated into the target site by a simple solvent exchange from oil to water. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | BIOMACROMOLECULES | - |
dc.subject | COMPLEX COACERVATION | - |
dc.subject | POLYELECTROLYTE MICROCAPSULES | - |
dc.subject | PHASE-SEPARATION | - |
dc.subject | TENSION | - |
dc.subject | PROTEIN | - |
dc.subject | ENCAPSULATION | - |
dc.subject | DELIVERY | - |
dc.subject | BEHAVIOR | - |
dc.subject | SHELL | - |
dc.title | Stabilizing Coacervate by Microfluidic Engulfment Induced by Controlled Interfacial Energy | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acs.biomac.9b01579 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMACROMOLECULES, v.21, no.2, pp.930 - 938 | - |
dc.identifier.wosid | 000513091100064 | - |
dc.citation.endPage | 938 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 930 | - |
dc.citation.title | BIOMACROMOLECULES | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Lee S. | - |
dc.contributor.affiliatedAuthor | Kim D.S. | - |
dc.contributor.affiliatedAuthor | Hwang D.S. | - |
dc.identifier.scopusid | 2-s2.0-85076556914 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | Chemical stability | - |
dc.subject.keywordPlus | Crosslinking | - |
dc.subject.keywordPlus | Microfluidics | - |
dc.subject.keywordPlus | Coacervate phase | - |
dc.subject.keywordPlus | Cross-linkers | - |
dc.subject.keywordPlus | Intrinsic property | - |
dc.subject.keywordPlus | Mechanical mixing | - |
dc.subject.keywordPlus | Micro-fluidic devices | - |
dc.subject.keywordPlus | Micro-particles | - |
dc.subject.keywordPlus | Salt concentration | - |
dc.subject.keywordPlus | Solvent exchanges | - |
dc.subject.keywordPlus | Interfacial energy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Polymer Science | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.