Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules
SCIE
SCOPUS
- Title
- Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules
- Authors
- Hwang W.; Yoo J.; Hwang I.-C.; Lee J.; Ko Y.H.; Kim H.W.; Kim Y.; Lee Y.; Hur M.Y.; Park K.M.; Seo J.; Baek K.; Kim K.
- Date Issued
- 2020-01
- Publisher
- WILEY-V C H VERLAG GMBH
- Abstract
- Hierarchical self-assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self-assembly of nanometer-sized tubulin heterodimers into protofilaments, which then associate to form micron-length-scale, multi-stranded tubes. This peculiar biological process is now mimicked with a fully synthetic molecule, which forms a 1:1 host-guest complex with cucurbit[7]uril as a globular building block, and then polymerizes into linear poly-pseudorotaxanes that associate laterally with each other in a self-shape-complementary manner to form a tubular structure with a length over tens of micrometers. Molecular dynamic simulations suggest that the tubular assembly consists of eight poly-pseudorotaxanes that wind together to form a 4.5 nm wide multi-stranded tubule.
- Keywords
- STRUCTURAL INSIGHTS; ORGANIZATION; DERIVATIVES; PROTEIN; TUBULES; DRIVEN
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/101206
- DOI
- 10.1002/anie.201913384
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020-01
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- There are no files associated with this item.
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