DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sable, Ganesh A. | - |
dc.contributor.author | Lee, Kang Ju | - |
dc.contributor.author | Lim, Hyun-Suk | - |
dc.date.accessioned | 2020-02-27T00:52:50Z | - |
dc.date.available | 2020-02-27T00:52:50Z | - |
dc.date.created | 2019-02-13 | - |
dc.date.issued | 2019-01 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/101238 | - |
dc.description.abstract | The development of peptidomimetic foldamers that can form well-defined folded structures is highly desirable yet challenging. We previously reported on -ABpeptoids, oligomers of N-alkylated (2)-homoalanines and found that due to the presence of chiral methyl groups at -positions, -ABpeptoids were shown to adopt folding conformations. Here, we report -ABpeptoids having chiral methyl group at -positions rather than -positions as a different class of peptoids with backbone chirality. We developed a facile solid-phase synthetic route that enables the synthesis of -ABpeptoid oligomers ranging from 2-mer to 8-mer in excellent yields. These oligomers were shown to adopt ordered folding conformations based on circular dichroism (CD) and NMR studies. Overall, these results suggest that -ABpeptoids represent a novel class of peptidomimetic foldamers that will find a wide range of applications in biomedical and material sciences. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | MOLECULES | - |
dc.title | Solid-Phase Synthesis and Circular Dichroism Study of -ABpeptoids | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/molecules24010178 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MOLECULES, v.24, no.1 | - |
dc.identifier.wosid | 000457150200178 | - |
dc.citation.number | 1 | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 24 | - |
dc.contributor.affiliatedAuthor | Lim, Hyun-Suk | - |
dc.identifier.scopusid | 2-s2.0-85059798682 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | AROMATIC SIDE-CHAINS | - |
dc.subject.keywordPlus | PEPTOID OLIGOMERS | - |
dc.subject.keywordPlus | CELL-PERMEABILITY | - |
dc.subject.keywordPlus | HELICAL FOLDAMERS | - |
dc.subject.keywordPlus | CYCLIC PEPTOIDS | - |
dc.subject.keywordPlus | BETA-PEPTOIDS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | REQUIREMENTS | - |
dc.subject.keywordPlus | SUBSTITUTION | - |
dc.subject.keywordAuthor | solid-phase synthesis | - |
dc.subject.keywordAuthor | peptidomimetics | - |
dc.subject.keywordAuthor | foldamers | - |
dc.subject.keywordAuthor | peptoids | - |
dc.subject.keywordAuthor | -ABpeptoids | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
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