DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Sung Kee | - |
dc.contributor.author | CHANG, YOUNG TAE | - |
dc.contributor.author | Ryu, Youngha | - |
dc.contributor.author | Moon, Sung-Hwan | - |
dc.date.accessioned | 2020-03-18T05:50:49Z | - |
dc.date.available | 2020-03-18T05:50:49Z | - |
dc.date.created | 2020-03-17 | - |
dc.date.issued | 1992-02 | - |
dc.identifier.issn | 1017-2548 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/101529 | - |
dc.description.abstract | Racemic myo-inositol-1,4,5-trisphosphate and myo-inositol-1,4-bisphosphate, which are respectively a second messenger mobilizing Ca2+ and its physiological metabolite in the intracellular signal transduction pathway, were synthesized from myo-inositol. Because of the conformational rigidity, isopropylidene ketals were used in the synthesis as suitable blocking groups of inositol. myo-Inositol-1,4-bisphosphate was synthesized through phosphorylation of the 1,4-diol(3) with diphenylphosphorochloridate and a subsequent deprotection. Regioselective deprotection of the trans-isopropylidene ketal over the cis-ketal was accomplished by a controlled acid hydrolysis. Partial hydrolysis of an orthoacetate was carried out in order to obtain the precursor which was regioselectively acetylated at the axially disposed 2-OH group over the equatorial 1-OH. Tetrabenzylpyrophosphate and N,N-diisopropyldibenzylphosphoramidite were used for effective phosphorylations of suitably functionalized precursors of myo-inositol 1,4,5-trisphosphate. Sequential deprotection afforded myo-inositol-1,4,5-trisphosphate without migration of phosphate groups. | - |
dc.language | English | - |
dc.publisher | Korean Chemical Society | - |
dc.relation.isPartOf | Journal of the Korean Chemical Society | - |
dc.title | Synthesis of myo-Inositol-1,4,5-trisphosphate and myo-Inositol-1,4-bisphosphate | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Journal of the Korean Chemical Society, v.2, no.1, pp.33 - 44 | - |
dc.citation.endPage | 44 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 33 | - |
dc.citation.title | Journal of the Korean Chemical Society | - |
dc.citation.volume | 2 | - |
dc.contributor.affiliatedAuthor | Chung, Sung Kee | - |
dc.contributor.affiliatedAuthor | CHANG, YOUNG TAE | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
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