Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination
SCIE
SCOPUS
- Title
- Enhanced immunogenicity and protective efficacy with the use of interleukin-12-encapsulated microspheres plus AS01B in tuberculosis subunit vaccination
- Authors
- Ha, SJ; Park, SH; Kim, HJ; Kim, SC; Kang, HJ; Lee, EG; Kwon, SG; Kim, BM; Lee, SH; Kim, WB; Sung, YC; Cho, SN
- Date Issued
- 2006-08
- Publisher
- AMER SOC MICROBIOLOGY
- Abstract
- Tuberculosis subunit vaccines codelivered with interleukin-12 (IL-12)-encapsulated microspheres (IL-12EM) are designed for a sustained release of IL-12 and could induce strong Th1 immune responses specific to Ag85A and ESAT-6. The adjuvant combination of IL-12EM plus AS01B was a more efficient way to induce a sustained Th1 immunity and protection against Mycobacterium tuberculosis.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/10407
- DOI
- 10.1128/IAI.01781-05
- ISSN
- 0019-9567
- Article Type
- Article
- Citation
- INFECTION AND IMMUNITY, vol. 74, no. 8, page. 4954 - 4959, 2006-08
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