3D Bioprinting of Multi-layered Tubular Constructs using Esophageal Tissue-derived Bioinks for Esophageal Regeneration
- Title
- 3D Bioprinting of Multi-layered Tubular Constructs using Esophageal Tissue-derived Bioinks for Esophageal Regeneration
- Authors
- Nam, Hyoryung; Jeong, Hun-Jin; Jo, Yeonggwon; Lee, Jae Yeon; Ha, Dong-Heon; Kim, Ji Hyun; Chung, Jae Hee; Cho, Young-Sam; Cho, Dong-Woo; Gwak, So-Jung; Lee, Seung-Jae; Jang, Jinah
- Date Issued
- 2020-08-28
- Publisher
- 한국조직공학 재생의학회
- Abstract
- The esophagus is located between the pharynx and stomach. It has a hollow passageway
structure that allows food to pass into the stomach. The incidence of esophageal diseases such
as esophageal cancer, esophageal stenosis, and esophageal atresia is increasing, but recovery is
difficult because of the weak esophageal regenerative ability. So, the treatments are performed
esophageal resection and reconstruction with a gastric pull-up, jejunal free flap. These methods
are prone to necrosis, sepsis, other complications, and in severe cases, death. [1] Therefore, an
alternative to existing treatments is needed. A tissue engineering-based approach has been
spotlighted recently. Most of the hollow structures being researched are manufactured by
electrospinning on the drum collector. However, it is difficult to produce free-form and multilayer structures and has poor mechanical properties. [2]
In this study, we developed an esophageal alternative construct by a new 3D printing technique
that stretches when the material is ejected through the nozzle. Moreover, the decellularized
esophageal bioinks were fabricated that mimic the composition of the esophageal tissue and
the microenvironment of each layer and were printed. The construct has not only to produce a
porous, free-form, multi-layered, and hollow structure but also mimic the morphological and
structural characteristics of the actual esophagus.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/106001
- Article Type
- Conference
- Citation
- 제21차 한국조직공학 재생의학회 학술대회, page. 140 - 140, 2020-08-28
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