DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Sookjin | - |
dc.contributor.author | Park, Yunji | - |
dc.contributor.author | Hyeon, Sumin | - |
dc.contributor.author | Kim, Young-Min | - |
dc.contributor.author | Kim, Ji-Hae | - |
dc.contributor.author | Kim, Hyekang | - |
dc.contributor.author | Park, Subin | - |
dc.contributor.author | Lee, Kun-Joo | - |
dc.contributor.author | Koo, Bon-Kyoung | - |
dc.contributor.author | Ha, Sang-Jun | - |
dc.contributor.author | Lee, Seung-Woo | - |
dc.date.accessioned | 2021-06-13T03:50:06Z | - |
dc.date.available | 2021-06-13T03:50:06Z | - |
dc.date.created | 2021-04-13 | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/106684 | - |
dc.description.abstract | Conventional CD4(+) T cells are differentiated into CD4(+)CD8 alpha alpha(+) intraepithelial lymphocytes (IELs) in the intestine; however, the roles of intestinal epithelial cells (IECs) are poorly understood. Here, we showed that IECs expressed MHC class II (MHC II) and programmed death-ligand 1 (PD-L1) induced by the microbiota and IFN-gamma in the distal part of the small intestine, where CD4(+) cells were transformed into CD4(+)CD8 alpha alpha(+) IELs. Therefore, IEC-specific deletion of MHC II and PD-L1 hindered the development of CD4(+)CD8 alpha alpha(+) IELs. Intracellularly, PD-1 signals supported the acquisition of CD8 alpha alpha by down-regulating the CD4-lineage transcription factor, T helper-inducing POZ/Kruppel-like factor (ThPOK), via the Src homology domain-containing tyrosine phosphatase (SHP) pathway. Our results demonstrate that noncanonical antigen presentation with cosignals from IECs constitutes niche adaptation signals to develop tissue-resident CD4(+)CD8 alpha alpha(+) IELs. | - |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.title | Niche-specific MHC II and PD-L1 regulate CD4(+)CD8 alpha alpha(+) intraepithelial lymphocyte differentiation | - |
dc.type | Article | - |
dc.identifier.doi | 10.1084/jem.20201665 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF EXPERIMENTAL MEDICINE, v.218, no.4 | - |
dc.identifier.wosid | 000630059700001 | - |
dc.citation.number | 4 | - |
dc.citation.title | JOURNAL OF EXPERIMENTAL MEDICINE | - |
dc.citation.volume | 218 | - |
dc.contributor.affiliatedAuthor | Moon, Sookjin | - |
dc.contributor.affiliatedAuthor | Park, Yunji | - |
dc.contributor.affiliatedAuthor | Hyeon, Sumin | - |
dc.contributor.affiliatedAuthor | Park, Subin | - |
dc.contributor.affiliatedAuthor | Lee, Kun-Joo | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Woo | - |
dc.identifier.scopusid | 2-s2.0-85101285339 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CD4(+) T-CELLS | - |
dc.subject.keywordPlus | TISSUE ADAPTATION | - |
dc.subject.keywordPlus | PRESENT ANTIGEN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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