Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging
SCIE
SCOPUS
- Title
- Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging
- Authors
- Kim, C; Qin, RG; Xu, JS; Wang, LV; Xu, R
- Date Issued
- 2010-01
- Publisher
- SPIE
- Abstract
- We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3302808]
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/10670
- DOI
- 10.1117/1.3302808
- ISSN
- 1083-3668
- Article Type
- Article
- Citation
- JOURNAL OF BIOMEDICAL OPTICS, vol. 15, no. 1, 2010-01
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