Au/Pt‐Egg‐in‐Nest Nanomotor for Glucose‐Powered Catalytic Motion and Enhanced Molecular Transport to Living Cells
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- Title
- Au/Pt‐Egg‐in‐Nest Nanomotor for Glucose‐Powered Catalytic Motion and Enhanced Molecular Transport to Living Cells
- Authors
- Kwon, Taewan; Kumari, Nitee; Kumar, Amit; Lim, Jongwon; Son, Chang Yun; Lee, In Su
- Date Issued
- 2021-08
- Publisher
- John Wiley & Sons Ltd.
- Abstract
- Nanostructures converting chemical energy to mechanical work by using benign metabolic fuels, have huge implications in biomedical science. Here, we introduce Au/Pt-based Janus nanostructures, resembling to "egg-in-nest" morphology (Au/Pt-ENs), showing enhanced motion as a result of dual enzyme-relay-like catalytic cascade in physiological biomedia, and in turn showing molecular-laden transport to living cells. We developed dynamic-casting approach using silica yolk-shell nanoreactors: first, to install a large Au-seed fixing the silica-yolk aside while providing the anisotropically confined concave hollow nanospace to grow curved Pt-dendritic networks. Owing to the intimately interfaced Au and Pt catalytic sites integrated in a unique anisotropic nest-like morphology, Au/Pt-ENs exhibited high diffusion rates and displacements as the result of glucose-converted oxygen concentration gradient. High diffusiophoresis in cell culture media increased the nanomotor-membrane interaction events, in turn facilitated the cell internalization. In addition, the porous network of Au/Pt-ENs facilitated the drug-molecule cargo loading and delivery to the living cells.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/106793
- DOI
- 10.1002/anie.202103827
- ISSN
- 1433-7851
- Article Type
- Article
- Citation
- Angewandte Chemie - International Edition, vol. 60, no. 32, page. 17579 - 17586, 2021-08
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