DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, GH | - |
dc.contributor.author | Her, JH | - |
dc.contributor.author | Han, JK | - |
dc.date.accessioned | 2015-06-25T02:17:51Z | - |
dc.date.available | 2015-06-25T02:17:51Z | - |
dc.date.created | 2009-03-18 | - |
dc.date.issued | 2008-09-22 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.other | 2015-OAK-0000008144 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10692 | - |
dc.description.abstract | The single-pass transmembrane protein Ryk (atypical receptor related tyrosine kinase) functions as a Wnt receptor. However, Ryk's correlation with Wnt/Frizzled (Fz) signaling is poorly understood. Here, we report that Ryk regulates Xenopus laevis convergent extension (CE) movements via the beta-arrestin 2 (beta arr2)-dependent endocytic process triggered by noncanonical Wnt signaling. During X. laevis gastrulation, beta arr2-mediated endocytosis of Fz7 and dishevelled (Dvl/Dsh) actually occurs in the dorsal marginal zone tissues, which actively participate in noncanonical Wnt signaling. Noncanonical Wnt11/Fz7-mediated endocytosis of Dsh requires the cell-membrane protein Ryk. Ryk interacts with both Wnt11 and beta arr2, cooperates with Fz7 to mediate Wnt11-stimulated endocytosis of Dsh, and signals the noncanonical Wnt pathway in CE movements. Conversely, depletion of Ryk and Wnt11 prevents Dsh endocytosis in dorsal marginal zone tissues. Our study suggests that Ryk functions as an essential regulator for noncanonical Wnt/Fz-mediated endocytosis in the regulation of X. laevis CE movements. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.relation.isPartOf | JOURNAL OF CELL BIOLOGY | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1083/jcb.200710188 | - |
dc.author.google | Kim, GH | en_US |
dc.author.google | Her, JH | en_US |
dc.author.google | Han, JK | en_US |
dc.relation.volume | 182 | en_US |
dc.relation.issue | 6 | en_US |
dc.relation.startpage | 1073 | en_US |
dc.relation.lastpage | 1082 | en_US |
dc.contributor.id | 10138853 | en_US |
dc.relation.journal | JOURNAL OF CELL BIOLOGY | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF CELL BIOLOGY, v.182, no.6, pp.1073 - 1082 | - |
dc.identifier.wosid | 000259403100007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1082 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1073 | - |
dc.citation.title | JOURNAL OF CELL BIOLOGY | - |
dc.citation.volume | 182 | - |
dc.contributor.affiliatedAuthor | Han, JK | - |
dc.identifier.scopusid | 2-s2.0-52249098269 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 78 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | CELL POLARITY | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | GASTRULATION | - |
dc.subject.keywordPlus | BETA-ARRESTIN-2 | - |
dc.subject.keywordPlus | INTERNALIZATION | - |
dc.subject.keywordPlus | ACCUMULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
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