DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tae Kang | - |
dc.contributor.author | Lee, June-Chul | - |
dc.contributor.author | IM, SIN HYEOG | - |
dc.contributor.author | Lee, Myung-Shik | - |
dc.date.accessioned | 2021-09-03T04:19:30Z | - |
dc.date.available | 2021-09-03T04:19:30Z | - |
dc.date.created | 2020-09-04 | - |
dc.date.issued | 2020-09 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/106953 | - |
dc.description.abstract | Type 1 autoimmune diabetes is an autoimmune disease characterized by specific destruction of pancreatic beta-cells producing insulin. Recent studies have shown that gut microbiota and immunity are closely linked to systemic immunity, affecting the balance between pro-inflammatory and regulatory immune responses. Altered gut microbiota may be causally related to the development of immune-mediated diseases, and probiotics have been suggested to have modulatory effects on inflammatory diseases and immune disorders. We studied whether a probiotic combination that has immunomodulatory effects on several inflammatory diseases can reduce the incidence of diabetes in non-obese diabetic (NOD) mice, a classical animal model of human T1D. When Immune Regulation and Tolerance 5 (IRT5), a probiotic combination comprisingLactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri, Bifidobacterium bifidium, andStreptococcus thermophiles, was administered 6 times a week for 36 weeks to NOD mice, beginning at 4 weeks of age, the incidence of diabetes was significantly reduced. Insulitis score was also significantly reduced, and beta-cell mass was conversely increased by IRT5 administration. IRT5 administration significantly reduced gut permeability in NOD mice. The proportion of total regulatory T cells was not changed by IRT5 administration; however, the proportion of CCR9(+)regulatory T (Treg) cells expressing gut-homing receptor was significantly increased in pancreatic lymph nodes (PLNs) and lamina propria of the small intestine (SI-LP). Type 1 T helper (Th1) skewing was reduced in PLNs by IRT5 administration. IRT5 could be a candidate for an effective probiotic combination, which can be safely administered to inhibit or prevent type 1 diabetes (T1D). | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.title | Amelioration of Autoimmune Diabetes of NOD Mice by Immunomodulating Probiotics | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fimmu.2020.01832 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, v.11 | - |
dc.identifier.wosid | 000570551400001 | - |
dc.citation.title | FRONTIERS IN IMMUNOLOGY | - |
dc.citation.volume | 11 | - |
dc.contributor.affiliatedAuthor | IM, SIN HYEOG | - |
dc.identifier.scopusid | 2-s2.0-85091017883 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | BETA-CELL DEATH | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IMMUNE HOMEOSTASIS | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | ONSET | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | PREVENTION | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | RESTORATION | - |
dc.subject.keywordAuthor | probiotics | - |
dc.subject.keywordAuthor | autoimmune diabetes | - |
dc.subject.keywordAuthor | regulatory T cells | - |
dc.subject.keywordAuthor | gut homing receptor | - |
dc.subject.keywordAuthor | gut permeability | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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