DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ramanjaneyulu, Bandaru T. | - |
dc.contributor.author | Vidyacharan, Shinde | - |
dc.contributor.author | Ahn, Gwang-Noh | - |
dc.contributor.author | Kim, Dong-Pyo | - |
dc.date.accessioned | 2021-12-03T10:00:14Z | - |
dc.date.available | 2021-12-03T10:00:14Z | - |
dc.date.created | 2020-06-04 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 2058-9883 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/107915 | - |
dc.description.abstract | We present an ultrafast approach for the synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, in 75% yield from benzo[d]oxazole-2-thiol and benzhydryl bromide via an unstable lithium thiolate intermediate in the presence of n-BuLi. The precisely controlled two-step reaction at room temperature in a simple capillary microreactor enables a drastic decrease of the synthesis time to milliseconds (580 ms) from 10 min in a flask. Furthermore, a simple continuous-flow operation of the low cost reactor readily realizes a high throughput, leading to a several gram scale production (approximately 4 g per 13.3 min) at a very high flow rate of 7.6 ml min(-1). | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | REACTION CHEMISTRY & ENGINEERING | - |
dc.title | Ultrafast synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, via an unstable lithium thiolate intermediate in a capillary microreactor | - |
dc.type | Article | - |
dc.identifier.doi | 10.1039/d0re00038h | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | REACTION CHEMISTRY & ENGINEERING, v.5, no.5, pp.849 - 852 | - |
dc.identifier.wosid | 000532366700003 | - |
dc.citation.endPage | 852 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 849 | - |
dc.citation.title | REACTION CHEMISTRY & ENGINEERING | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | Ahn, Gwang-Noh | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Pyo | - |
dc.identifier.scopusid | 2-s2.0-85086011781 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CATALYZED C-S | - |
dc.subject.keywordPlus | FLOW CHEMISTRY | - |
dc.subject.keywordPlus | STEREOCONTROLLED SYNTHESIS | - |
dc.subject.keywordPlus | ASYMMETRIC-SYNTHESIS | - |
dc.subject.keywordPlus | BOND FORMATION | - |
dc.subject.keywordPlus | BORONIC ACIDS | - |
dc.subject.keywordPlus | ARYL | - |
dc.subject.keywordPlus | GREEN | - |
dc.subject.keywordPlus | SULFIDES | - |
dc.subject.keywordPlus | TECHNOLOGY | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Engineering, Chemical | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Engineering | - |
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