Visualization of lipophagy using a supramolecular FRET pair
SCIE
SCOPUS
- Title
- Visualization of lipophagy using a supramolecular FRET pair
- Authors
- Lee, Ara; Li, Meng; Ko, Young Ho; Park, Sanghwang; Seo, Jongcheol; Park, Kyeng Min; Kim, Kimoon
- Date Issued
- 2021-11
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- A rationally designed supramolecular FRET pair consisting of cyanine3-cucurbit[7]uril (Cy3-CB[7]) and boron-dipyrromethene 630/650-adamantylammonium (BDP-AdA) can be used to visualize organelle-specific autophagy events. The intracellular accumulations of Cy3-CB[7] in lysosomes and BDP-AdA in lipid droplets (LDs) and the formation of an intracellular host-guest complex between Cy3-CB[7] and BDP-AdA resulting in FRET signals allow us to visualize the fusion of LDs with lysosomes, namely, lipophagy. This study demonstrates the potential of supramolecular imaging based on bio-orthogonal host-guest interactions in the investigation of selective autophagy events.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109504
- DOI
- 10.1039/d1cc04779e
- ISSN
- 1359-7345
- Article Type
- Article
- Citation
- CHEMICAL COMMUNICATIONS, vol. 57, no. 91, page. 12179 - 12182, 2021-11
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.