Increased excitation-inhibition balance of the cortex in the mouse model of the focal malformation of cortical development
- Title
- Increased excitation-inhibition balance of the cortex in the mouse model of the focal malformation of cortical development
- Authors
- BAEK, SEUNG TAE; 김예은; Kim, Yong-Seok; Rah, Jong-Cheol
- Date Issued
- 2020-11-17
- Publisher
- 한국뇌신경과학회
- Abstract
- A typical symptom of epilepsy, a type of neurological disorder, includes a
seizure caused by the sudden and disorderly over-excitement of neurons.
This symptom can be controlled by medication in ~80 % of patients but not
in ~20% of the intractable cases due to the gap between the target of the
anticonvulsants and the causes. In the current study, we explored the abnormality
of the circuits in the mouse model of focal malformation of cortical
development (FMCD), which shows the intractable seizure.
We found that the FMCD mouse model shows an increased intrinsic excitability
not only in the neurons with somatic mutation, but also in neighboring
neurons throughout cortical layers. Pyramidal neurons in the cortex
with FMCD showed increased excitability by increased input resistance and
depolarized resting membrane potential. In addition, a significant increase
in the HCN-dependent rebounding current was observed in the mutant neurons.
Consistently, we observed a dramatic decrease in the rheobase and
increase in the firing frequency in response to the same amount of current
injection. Furthermore, we found that the frequency of spontaneous inhibitory
postsynaptic current (sIPSC) was significantly reduced. The reduction
in the frequency of sIPSC can be attributed to reduction in (1) the excitability,
(2) the release probability, or the number of inhibitory neurons of the
cortical circuit. To distinguish these possibilities, we are currently analyzing
the pathological features of the inhibitory neurons in FMCD mouse model.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/109782
- Article Type
- Conference
- Citation
- KSBNS 2020, 2020-11-17
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