DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, H | - |
dc.contributor.author | Youn, H | - |
dc.contributor.author | Lee, S | - |
dc.contributor.author | Ban, C | - |
dc.date.accessioned | 2015-06-25T02:27:15Z | - |
dc.date.available | 2015-06-25T02:27:15Z | - |
dc.date.created | 2015-02-04 | - |
dc.date.issued | 2014-08-14 | - |
dc.identifier.issn | 2050-750X | - |
dc.identifier.other | 2015-OAK-0000031444 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/10989 | - |
dc.description.abstract | Although various studies related to nanoparticles-based photothermal therapy have been actively performed, an epoch-making photothermolysis therapy exhibiting both high selectivity and efficiency has yet not been discovered. For the first time, we have developed novel valuable therapeutic complexes, namely, dual aptamer-modified gold nanostars, for the targeting of prostate cancers, including PSMA(+) and PSMA(-) cells. The synthesized probes were characterized through several techniques, including UV-VIS spectral analysis, DLS analysis, zeta potential measurements, and TEM imaging, and were subsequently subjected to cytotoxicity tests, cell uptake confirmation, and in vitro photothermat therapy. The homogeneously well-fabricated nanostars presented high selectivity to prostate cancer cells and extremely high efficiency for therapy using an 808 nm laser under an irradiance of 0.3 W cm(-2), which is lower than the permitted value for skin exposure (0.329 W cm(-2)). It is anticipated that this novel photothermal agent will become the general platform for targeted therapy. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.relation.isPartOf | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Ultra-effective photothermal therapy for prostate cancer cells using dual aptamer-modified gold nanostars | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | en_US |
dc.identifier.doi | 10.1039/C4TB00643G | - |
dc.author.google | Jo, H | en_US |
dc.author.google | Youn, H | en_US |
dc.author.google | Ban, C | en_US |
dc.author.google | Lee, S | en_US |
dc.relation.volume | 2 | en_US |
dc.relation.issue | 30 | en_US |
dc.relation.startpage | 4862 | en_US |
dc.relation.lastpage | 4867 | en_US |
dc.contributor.id | 10085220 | en_US |
dc.relation.journal | JOURNAL OF MATERIALS CHEMISTRY B | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | JOURNAL OF MATERIALS CHEMISTRY B, v.2, no.30, pp.4862 - 4867 | - |
dc.identifier.wosid | 000339469000010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 4867 | - |
dc.citation.number | 30 | - |
dc.citation.startPage | 4862 | - |
dc.citation.title | JOURNAL OF MATERIALS CHEMISTRY B | - |
dc.citation.volume | 2 | - |
dc.contributor.affiliatedAuthor | Ban, C | - |
dc.identifier.scopusid | 2-s2.0-84904167419 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 18 | - |
dc.description.scptc | 19 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ANTIBODIES | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | NANOCAGES | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Materials Science | - |
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