Design of Liquid Crystalline Carrier of Ceramide
- Title
- Design of Liquid Crystalline Carrier of Ceramide
- Authors
- 최영선; 김혜인; 오광석; KIM, YOUNGKI
- Date Issued
- 2022-02-10
- Publisher
- 한국정보디스플레이학회
- Abstract
- Ceramides, which compose skin barrier, play a crucial role in preventing skin dehydration. Thus, supplying much of ceramides to skin is an important goal in cosmetic applications. To contain ceramides in cosmetics, lyotropic liquid crystals (LLCs) has been used as a carrier. However, hydrophobicity and hydrogen bonds of ceramides, which cause condensation in aqueous solutions, limit the content of ceramides.(<1 wt%) [1]. Also, LLC carriers in aqueous solutions are not intrinsically unstable due to their hydrophilic nature. Here, to overcome the previous limitations, we propose a cholesterol-based thermotropic liquid crystals (CLCs) for the ceramides carrier that have not only biocompatible but also hydrophobic nature. We confirm self-assembly of ceramides by transition of CLC droplets texture from planar to perpendicular. The result demonstrates that the presence of hydrophobic (CLC)-hydrophilic (aqueous solution) interface facilitate the self-assembly of ceramides at the interface because of amphiphilic properties of ceramides. Thus, thermotropic LCs carrier significantly increase the doping concentration of ceramides in the aqueous solution.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/110408
- Article Type
- Conference
- Citation
- 한국액정학술대회, 2022-02-10
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.