Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
SCIE
SCOPUS
- Title
- Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
- Authors
- Jin, J; Lee, WS; Joo, KM; Maiti, KK; Biswas, G; Kim, W; Kim, KT; Lee, SJ; Kim, KH; Nam, DH; Chung, SK
- Date Issued
- 2011-04
- Publisher
- ROYAL SOC CHEMISTRY
- Abstract
- The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/11366
- DOI
- 10.1039/C0MD00235F
- ISSN
- 2040-2503
- Article Type
- Article
- Citation
- MEDCHEMCOMM, vol. 2, no. 4, page. 270 - 273, 2011-04
- Files in This Item:
-
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.