Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule–actin crosstalk during neurodevelopment
SCIE
SCOPUS
- Title
- Gcap14 is a microtubule plus-end-tracking protein coordinating microtubule–actin crosstalk during neurodevelopment
- Authors
- MUN, DONG JIN; GOO, BON SEONG; SUH, BOKYOUNG; Hong, Ji-Ho; WOO, YOUNGSIK; KIM, SOO JEONG; Kim, Seunghyun; LEE, SUBEEN; Won, Yubin; YOO, JINYEONG; CHO, EUNBYUL; Jang, Eun Jin; Nhung, Truong Thi My; Triet, Hong Minh; An, Hongyul; Lee, Haeryun; Nguyen, Minh Dang; Park, Seung-Yeol; Baek, Seung Tae; PARK, SANG KI
- Date Issued
- 2023-02
- Publisher
- National Academy of Sciences
- Abstract
- Regulation of microtubule dynamics is required to properly control various steps of neurodevelopment. In this study, we identified granule cell antiserum-positive 14 (Gcap14) as a microtubule plus-end-tracking protein and as a regulator of microtubule dynamics during neurodevelopment. Gcap14 knockout mice exhibited impaired cortical lamination. Gcap14 deficiency resulted in defective neuronal migration. Moreover, nuclear distribution element nudE-like 1 (Ndel1), an interacting partner of Gcap14, effectively corrected the downregulation of microtubule dynamics and the defects in neuronal migration caused by Gcap14 deficiency. Finally, we found that the Gcap14–Ndel1 complex participates in the functional link between microtubule and actin filament, thereby regulating their crosstalks in the growth cones of cortical neurons. Taken together, we propose that the Gcap14–Ndel1 complex is fundamental for cytoskeletal remodeling during neurodevelopmental processes such as neuronal processes elongation and neuronal migration.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116048
- DOI
- 10.1073/pnas.2214507120
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 8, 2023-02
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