DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cho Sungwoo | - |
dc.contributor.author | Shon Min Ju | - |
dc.contributor.author | Son Boram | - |
dc.contributor.author | Eun Gee Sung | - |
dc.contributor.author | Yoon Tae-Young | - |
dc.contributor.author | Park Tai Hyun | - |
dc.date.accessioned | 2023-03-02T06:22:23Z | - |
dc.date.available | 2023-03-02T06:22:23Z | - |
dc.date.created | 2023-03-02 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 2772-9508 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/116173 | - |
dc.description.abstract | Cells can ???sense??? physical cues in the surrounding microenvironment and ???react??? by changing their function. Previous studies have focused on regulating the physical properties of the matrix, such as stiffness and topog-raphy, thus changing the tension ???felt??? by the cell as a result. In this study, by directly applying a quantified magnetic force to the cell, a correlation between differentiation and tension was shown. The magnetic force, quantified by magnetic tweezers, was applied by incorporating magnetotactic bacteria-isolated magnetic nanoparticles (MNPs) in human mesenchymal stem cells. As the applied tension increased, the expression levels of osteogenic differentiation marker genes and proteins were proportionally upregulated. Additionally, the translocation of YAP and RUNX2, deformation of nucleus, and activation of the MAPK signaling pathway were observed in tension-based osteogenic differentiation. Our findings provide a platform for the quantitative control of tension, a key factor in stem cell differentiation, between cells and the matrix using MNPs. Furthermore, these findings improve the understanding of osteogenic differentiation by mechanotransduction. | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | Biomaterials Advances | - |
dc.title | Tension exerted on cells by magnetic nanoparticles regulates differentiation of human mesenchymal stem cells | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.bioadv.2022.213028 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials Advances, v.139 | - |
dc.identifier.wosid | 000838260600003 | - |
dc.citation.title | Biomaterials Advances | - |
dc.citation.volume | 139 | - |
dc.contributor.affiliatedAuthor | Shon Min Ju | - |
dc.identifier.scopusid | 2-s2.0-85134849049 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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