Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy
SCIE
SCOPUS
- Title
- Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy
- Authors
- Baipaywad, Phornsawat; Ryu, Naeun; Im, Soo-Seok; Lee, Ukjae; Son, Hyung Bin; Kim, Won Jong; Park, Hansoo
- Date Issued
- 2022-01
- Publisher
- Taylor and Francis Ltd.
- Abstract
- © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(N-isopropylacrylamide) (PNIPAM)-based nanogel systems containing GO for controlled in vitro drug delivery. The photothermal effects of the PNIPAM/GO- and PNIPAMAAM/GO-based nanogel systems were enhanced. The release of DOX from the PNIPAM/GO-based nanogel was achieved using the photothermal effect of near-infrared irradiation. Using a Cell Counting Kit-8 assay, the cytotoxicity of all conditions demonstrated that the PNIPAM composite-based nanogels were biocompatible with no significance.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/116179
- DOI
- 10.1080/15685551.2022.2111854
- ISSN
- 1385-772X
- Article Type
- Article
- Citation
- Designed Monomers and Polymers, vol. 25, no. 1, page. 245 - 253, 2022-01
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