Thesis
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | 윤소영 | - |
| dc.date.accessioned | 2023-04-07T16:37:20Z | - |
| dc.date.available | 2023-04-07T16:37:20Z | - |
| dc.date.issued | 2022 | - |
| dc.identifier.other | OAK-2015-09960 | - |
| dc.identifier.uri | http://postech.dcollection.net/common/orgView/200000640787 | ko_KR |
| dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/117414 | - |
| dc.description | Master | - |
| dc.description.abstract | Long non-coding RNAs (lncRNAs) have various effects in cancer mostly through regulating gene expression. lncRNA NR2F1-AS1 is known to promote tumor progression in endometrial cancer, hepatocellular carcinoma, and thyroid cancer. However, the role of lncRNA NR2F1-AS1 in neuroendocrine cancer (NEPC) development remains unknown. In this study, I found that lncRNA NR2F1-AS1 expression was increased and positively correlated with that of NR2F1 in NEPC through in vitro cell line tests and patient data analysis. Knockdown of lncRNA NR2F1-AS1 reduced neuroendocrine marker (NE-marker) expression at the protein level. Moreover, the overexpression of NR2F1 increased the levels of SOX2, which is an important transcription factor for reprogramming and NEPC development, in NR2F1-AS1 knockdown PC-3 cells. These results imply that lncRNA NR2F1-AS1 could promote the development of NEPC through regulating NR2F1 and SOX2 expression. | - |
| dc.language | eng | - |
| dc.publisher | 포항공과대학교 | - |
| dc.title | The role of lncRNA NR2F1-AS1 in neuroendocrine prostate cancer | - |
| dc.type | Thesis | - |
| dc.contributor.college | 생명과학과 | - |
| dc.date.degree | 2022- 8 | - |
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