Human-T-Cell-Selective Fluorescent Probe
SCIE
SCOPUS
- Title
- Human-T-Cell-Selective Fluorescent Probe
- Authors
- Gao, Min; Chang, Young-Tae
- Date Issued
- 2022-09
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Abstract
- The identification of T and B lymphocytes has relied on using antibodies against different biomarkers as the gold standard. Emerging small molecule-based fluorescent probes have the potential to replace antibodies. Herein, we report the first human-T-cell-selective fluorescent probe, Mito thermo yellow (MTY), achieving the live T cells' distinction from B cells, which was previously impossible without the help of antibodies. The unexpected cell selectivity of MTY is attributed to the higher mitochondria mass and membrane potential of T cells over B cells. This study enriches the toolbox for live cell distinction from complex cell communities.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/117889
- DOI
- 10.3390/cells11182836
- Article Type
- Article
- Citation
- Cells, vol. 11, no. 18, 2022-09
- Files in This Item:
- There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.