DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, H | - |
dc.contributor.author | Kim, BG | - |
dc.contributor.author | Han, WH | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Cho, JY | - |
dc.contributor.author | Park, WS | - |
dc.contributor.author | Maurice, MM | - |
dc.contributor.author | Han, JK | - |
dc.contributor.author | Lee, MJ | - |
dc.contributor.author | Finley, D | - |
dc.contributor.author | Jho, EH | - |
dc.date.accessioned | 2015-06-25T02:54:26Z | - |
dc.date.available | 2015-06-25T02:54:26Z | - |
dc.date.created | 2014-03-06 | - |
dc.date.issued | 2013-08 | - |
dc.identifier.issn | 2157-9024 | - |
dc.identifier.other | 2015-OAK-0000029190 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/11855 | - |
dc.description.abstract | Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. Mutations in the RDU resulted in accumulation of polyubiquitinated forms of Dvl, which were mainly K63 linked. Small interfering RNA-based screening identified Usp14 as a mediator of Dvl deubiquitination. Genetic and chemical suppression of Usp14 activity caused an increase in Dvl polyubiquitination and significantly impaired downstream Wnt signaling. These data suggest that Usp14 functions as a positive regulator of the Wnt signaling pathway. Consistently, tissue microarray analysis of colon cancer revealed a strong correlation between the levels of Usp14 and b-catenin, which suggests an oncogenic role for Usp14 via enhancement of Wnt/beta-catenin signaling. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | ONCOGENESIS | - |
dc.relation.isPartOf | ONCOGENESIS | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1038/ONCSIS.2013.28 | - |
dc.author.google | Jung H., Kim B.-G., Han W.H., Lee J.H., Cho J.-Y., Park W.S., Maurice M.M., Han J.-K., Lee M.J., Finley D., Jho E.-H. | en_US |
dc.relation.volume | 2013 | en_US |
dc.relation.issue | 2 | en_US |
dc.relation.startpage | E64 | en_US |
dc.relation.lastpage | E64 | en_US |
dc.contributor.id | 10138853 | en_US |
dc.relation.journal | ONCOGENESIS | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCIE | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | ONCOGENESIS, v.2013, no.2, pp.E64 - E64 | - |
dc.identifier.wosid | 000209220400006 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | E64 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | E64 | - |
dc.citation.title | ONCOGENESIS | - |
dc.citation.volume | 2013 | - |
dc.contributor.affiliatedAuthor | Han, JK | - |
dc.identifier.scopusid | 2-s2.0-84883185607 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 43 | - |
dc.description.scptc | 43 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | UBIQUITIN RECOGNITION | - |
dc.subject.keywordPlus | COLORECTAL-CANCER | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DOMAIN | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | PROTEASOME | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | Wnt | - |
dc.subject.keywordAuthor | dishevelled | - |
dc.subject.keywordAuthor | deubiquitinase | - |
dc.subject.keywordAuthor | Usp14 | - |
dc.subject.keywordAuthor | ubiquitination | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
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