DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Geunho | - |
dc.contributor.author | An, Seoung Hyun | - |
dc.contributor.author | Choi, Jae-Won | - |
dc.contributor.author | Rho, Mee Sook | - |
dc.contributor.author | Park, Woo Chan | - |
dc.contributor.author | Jeong, Woo jin | - |
dc.contributor.author | Cha, Hyung Joon | - |
dc.date.accessioned | 2024-03-04T06:40:36Z | - |
dc.date.available | 2024-03-04T06:40:36Z | - |
dc.date.created | 2024-02-29 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/120706 | - |
dc.description.abstract | Retinal detachment and other vision-threatening disorders often necessitate vitreous body removal and tamponade injection for retina stabilization. Current clinical tamponades such as silicone oil and expansile gases have drawbacks, including patient discomfort and the need for secondary surgery. We introduce a transparent alginate-phenylboronic acid/polyvinyl alcohol composite hydrogel (TALPPH) as a novel vitreous substitute with tamponading capabilities. In vitro physicochemical, rheological, and optical characterization of in situ selfhealable TALPPH was performed, and long-term biocompatibility was assessed in a rabbit model of vitrectomy retinal detachment. In vivo evaluations confirmed TALPPH's ability to inhibit retinal detachment recurrence and preserve rabbit vision without adverse effects. TALPPH's close resemblance to the natural vitreous body suggests potential as a vitreous tamponade substitute for future ophthalmological applications. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.title | Injectable alginate-based in situ self-healable transparent hydrogel as a vitreous substitute with a tamponading function | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2023.122459 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.305 | - |
dc.identifier.wosid | 001156608700001 | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 305 | - |
dc.contributor.affiliatedAuthor | Choi, Geunho | - |
dc.contributor.affiliatedAuthor | Cha, Hyung Joon | - |
dc.identifier.scopusid | 2-s2.0-85181954417 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SILICONE OIL | - |
dc.subject.keywordPlus | RETINAL-DETACHMENT | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | RABBIT | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | BODY | - |
dc.subject.keywordAuthor | In situ crosslinking | - |
dc.subject.keywordAuthor | Retinal detachment | - |
dc.subject.keywordAuthor | Viscoelastic hydrogel | - |
dc.subject.keywordAuthor | Transparent hydrogel | - |
dc.subject.keywordAuthor | Vitreous tamponade | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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