A tissue injury sensing and repair pathway distinct from host pathogen defense
SCIE
SCOPUS
- Title
- A tissue injury sensing and repair pathway distinct from host pathogen defense
- Authors
- Liu, Siqi; Hur, Yun Ha; Cai, Xin; Cong, Qian; Yang, Yihao; Xu, Chiwei; Bilate, Angelina M.; Gonzales, Kevin Andrew Uy; Parigi, S. Martina; Cowley, Christopher J.; Hurwitz, Brian; Luo, Ji-Dung; Tseng, Tiffany; Gur-Cohen, Shiri; Sribour, Megan; Omelchenko, Tatiana; Levorse, John; Pasolli, Hilda Amalia; Thompson, Craig B.; Mucida, Daniel; Fuchs, Elaine
- Date Issued
- 2023-05
- Publisher
- Cell Press
- Abstract
- Pathogen infection and tissue injury are universal insults that disrupt homeostasis. Innate immunity senses microbial infections and induces cytokines/chemokines to activate resistance mechanisms. Here, we show that, in contrast to most pathogen-induced cytokines, interleukin-24 (IL-24) is predominately induced by barrier epithelial progenitors after tissue injury and is independent of microbiome or adaptive immunity. Moreover, Il24 ablation in mice impedes not only epidermal proliferation and re-epithelialization but also capillary and fibroblast regeneration within the dermal wound bed. Conversely, ectopic IL-24 induction in the homeostatic epidermis triggers global epithelial-mesenchymal tissue repair responses. Mechanistically, Il24 expression depends upon both epithelial IL24-receptor/STAT3 signaling and hypoxia-stabilized HIF1α, which converge following injury to trigger autocrine and paracrine signaling involving IL-24-mediated receptor signaling and metabolic regulation. Thus, parallel to innate immune sensing of pathogens to resolve infections, epithelial stem cells sense injury signals to orchestrate IL-24-mediated tissue repair. © 2023 The Authors
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/120852
- DOI
- 10.1016/j.cell.2023.03.031
- ISSN
- 0092-8674
- Article Type
- Article
- Citation
- Cell, vol. 186, no. 10, page. 2127 - 2143.e22, 2023-05
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