Formal Synthesis of (+)-Sinefungin by Way of Sequential Asymmetric Metal Catalysis
SCIE
SCOPUS
- Title
- Formal Synthesis of (+)-Sinefungin by Way of Sequential Asymmetric Metal Catalysis
- Authors
- Dey, Raghunath; Jang, Dong-Jin; Rhee, Young Ho
- Date Issued
- 2024-04
- Publisher
- American Chemical Society
- Abstract
- Here, we report a de novo approach toward (+)-sinefungin, a potent inhibitor of the physiological methyl transfer process. A key feature is represented by the sequential metal catalysis combining Pd-catalyzed hydroalkoxylation and ring-rearrangement metathesis. The unique advantage of the method is highlighted by the unprecedented complete control of the C-6 stereocenter.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/123779
- DOI
- 10.1021/acs.orglett.4c01196
- ISSN
- 1523-7060
- Article Type
- Article
- Citation
- Organic Letters, vol. 26, no. 18, page. 3957 - 3960, 2024-04
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