DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hyun Sun | - |
dc.contributor.author | Yun, Jinyoung | - |
dc.contributor.author | Jeong, Yeonsu | - |
dc.contributor.author | Jo, Yun Kee | - |
dc.contributor.author | CHA, HYUNG JOON | - |
dc.date.accessioned | 2024-08-07T06:41:40Z | - |
dc.date.available | 2024-08-07T06:41:40Z | - |
dc.date.created | 2024-08-01 | - |
dc.date.issued | 2024-03 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/123836 | - |
dc.description.abstract | Periprosthetic infection is a devastating postimplantation complication in which a biofilm layer harboring invasive microorganisms forms around orthopedic implants, leading to severe implant failure and patient morbidity. Despite the development of several infection-triggered antibiotic release approaches, most current antibacterial coatings are susceptible to undesired antibiotic leakage or mechanical disintegration during prosthesis installation. Herein, we propose a self-controllable proteinic antibacterial coating capable of both longlasting adherence onto titanium implant substrates over the implant fixation period and instantaneous bacterial eradication. Importantly, the pH-dependent reversible metal coordination of mussel adhesive protein (MAP) enabled bacterial concentration-dependent antibiotic delivery in response to infection-induced acidification. In addition, the MAP coating exhibited superior self-healable adhesive properties and scratch resistance, which enabled to avert issues associated with mechanical damages, including peeling and cracking, often occurring in conventional implant coating systems. The gentamicin-loaded MAP coating exhibited complete inhibition of bacterial growth in vivo against Staphylococcus aureus penetrations during implantation surgery (immediate infection) and even 4 weeks after implantation (delayed infection). Thus, our antibiotic-loaded MAP hydrogel coating can open new avenues for self-defensive antibiotic prophylaxis to achieve instant and sustainable bacteriocidal activity in orthopedic prostheses. (c) 2017 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.relation.isPartOf | Biomaterials | - |
dc.title | Self-controllable proteinic antibacterial coating with bacteria-triggered antibiotic release for prevention of periprosthetic infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.biomaterials.2023.122457 | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials, v.305 | - |
dc.identifier.wosid | 001165443200001 | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 305 | - |
dc.contributor.affiliatedAuthor | CHA, HYUNG JOON | - |
dc.identifier.scopusid | 2-s2.0-85181662728 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | N | - |
dc.type.docType | Article | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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