DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Xu, H | - |
dc.contributor.author | Montell, C | - |
dc.date.accessioned | 2015-06-25T03:26:45Z | - |
dc.date.available | 2015-06-25T03:26:45Z | - |
dc.date.created | 2016-02-15 | - |
dc.date.issued | 2004-08-10 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2015-OAK-0000019888 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12727 | - |
dc.description.abstract | A feature shared between Drosophila rhodopsin and nearly all other G protein-coupled receptors is agonist-dependent protein phosphorylation. Despite extensive analyses of Drosophila photo-transduction, the identity and function of the rhodopsin kinase (RK) have been elusive. Here, we provide evidence that G protein-coupled receptor kinase 1 (GPRK1), which is most similar to the beta-adrenergic receptor kinases, G protein-coupled receptor kinase 2 (GRK2) and GRK3, is the fly RK. We show that GPRK1 is enriched in photoreceptor cells, associates with the major Drosophila rhodopsin, Rh1, and phosphorylates the receptor. As is the case with mammalian GRK2 and GRK3, Drosophila GPRK1 includes a C-terminal pleckstrin homology domain, which binds to phosphoinositides and the Gbetagamma subunit. To address the role of GPRK1, we generated transgenic flies that expressed higher and lower levels of RK activity. Those flies with depressed levels of RK activity displayed a light response with a much larger amplitude than WT. Conversely, the amplitude of the light response was greatly suppressed in transgenic flies expressing abnormally high levels of RK activity. These data point to an evolutionarily conserved role for GPRK1 in modulating the amplitude of the visual response. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | en_US |
dc.identifier.doi | 10.1073/PNAS.0402205 | - |
dc.author.google | Lee, SJ | en_US |
dc.author.google | Xu, H | en_US |
dc.author.google | Montell, C | en_US |
dc.relation.volume | 101 | en_US |
dc.relation.issue | 32 | en_US |
dc.relation.startpage | 11874 | en_US |
dc.relation.lastpage | 11879 | en_US |
dc.contributor.id | 10201212 | en_US |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.101, no.32, pp.11874 - 11879 | - |
dc.identifier.wosid | 000223276700062 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 11879 | - |
dc.citation.number | 32 | - |
dc.citation.startPage | 11874 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 101 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 28 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | COUPLED RECEPTOR KINASE | - |
dc.subject.keywordPlus | PROTEIN PHOSPHATASE | - |
dc.subject.keywordPlus | MICE LACKING | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | DESENSITIZATION | - |
dc.subject.keywordPlus | ARRESTIN | - |
dc.subject.keywordPlus | DEGENERATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | SUPERSENSITIVITY | - |
dc.subject.keywordPlus | PHOTORECEPTORS | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.