DC Field | Value | Language |
---|---|---|
dc.contributor.author | Murphy, CT | - |
dc.contributor.author | Lee, SJ | - |
dc.contributor.author | Kenyon, C | - |
dc.date.accessioned | 2015-06-25T03:27:23Z | - |
dc.date.available | 2015-06-25T03:27:23Z | - |
dc.date.created | 2011-05-09 | - |
dc.date.issued | 2007-11-27 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.other | 2015-OAK-0000019885 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/12742 | - |
dc.description.abstract | How are the rates of aging of different tissues coordinated? In Caenorhabditis elegans, decreasing insulin/IGF-1 signaling extends lifespan by activating the transcription factor DAF-16/FOXO. If DAF-16 levels are experimentally increased in one tissue, such as the intestine, DAF-16 activity in other tissues rises. Here we test the hypothesis that this '' FOXO-to-FOXO '' signaling occurs via feedback regulation of ins-7 insulin gene expression. We find that DAF-16 regulates ins-7 expression in the intestine, and that preventing this regulation blocks FOXO-to-FOXO signaling from the intestine to other tissues. Our findings show that feedback regulation of insulin gene expression coordinates DAF-16 activity among the tissues, and they establish the intestine, which is the animal's entire endoderm, as an important insulin-signaling center. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Tissue entrainment by feedback regulation of insulin gene expression in the endoderm of Caenorhabditis elegans | - |
dc.type | Article | - |
dc.contributor.college | 정보전자융합공학부 | en_US |
dc.identifier.doi | 10.1073/PNAS.0709613104 | - |
dc.author.google | Murphy, CT | en_US |
dc.author.google | Lee, SJ | en_US |
dc.author.google | Kenyon, C | en_US |
dc.relation.volume | 104 | en_US |
dc.relation.issue | 48 | en_US |
dc.relation.startpage | 19046 | en_US |
dc.relation.lastpage | 19050 | en_US |
dc.contributor.id | 10201212 | en_US |
dc.relation.journal | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.48, pp.19046 - 19050 | - |
dc.identifier.wosid | 000251498700033 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 19050 | - |
dc.citation.number | 48 | - |
dc.citation.startPage | 19046 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 104 | - |
dc.contributor.affiliatedAuthor | Lee, SJ | - |
dc.identifier.scopusid | 2-s2.0-37649022616 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 88 | - |
dc.description.scptc | 95 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | LIFE-SPAN | - |
dc.subject.keywordPlus | DAF-16 | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | DIAPAUSE | - |
dc.subject.keywordPlus | MEMBER | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | aging | - |
dc.subject.keywordAuthor | DAF-2 | - |
dc.subject.keywordAuthor | DAF-16 | - |
dc.subject.keywordAuthor | FOXO | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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