DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, E | - |
dc.contributor.author | Park, S | - |
dc.contributor.author | Choi, N | - |
dc.contributor.author | Lee, J | - |
dc.contributor.author | Yoe, J | - |
dc.contributor.author | Kim, S | - |
dc.contributor.author | Jung, HY | - |
dc.contributor.author | KIM, KYONG TAI | - |
dc.contributor.author | Kang, H | - |
dc.contributor.author | Fryer, JD | - |
dc.contributor.author | Zoghbi, HY | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | LEE, YOONTAE | - |
dc.date.accessioned | 2015-07-07T19:03:45Z | - |
dc.date.available | 2015-07-07T19:03:45Z | - |
dc.date.created | 2015-02-23 | - |
dc.date.issued | 2015-02-05 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.other | 2015-OAK-0000032147 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13061 | - |
dc.description.abstract | Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L-/-) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines. We discovered that several drug metabolism and BA transporter genes were down-regulated in Cic-L-/- liver, and that BA was increased in the liver and serum whereas bile was decreased within the gallbladder of Cic-L-/- mice. We also found that levels of proinflammatory cytokine genes were up-regulated in Cic-L-/- liver. Consistent with this finding, levels of hepatic transcriptional regulators, such as hepatic nuclear factor 1 alpha (HNF1 alpha), CCAAT/enhancer-binding protein beta (C/EBP beta), forkhead box protein A2 (FOXA2), and retinoid X receptor alpha (RXR alpha), were markedly decreased in Cic-L-/- mice. Moreover, induction of tumor necrosis factor alpha (Tnf alpha) expression and decrease in the levels of FOXA2, C/EBP beta, and RXRa were found in Cic-L-/- liver before BA was accumulated, suggesting that inflammation might be the cause for the cholestasis in Cic-L-/- mice. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | nature publishing group | - |
dc.relation.isPartOf | Scientific Reports | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.title | Deficiency of Capicua disrupts bile acid homeostasis | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | en_US |
dc.identifier.doi | 10.1038/SREP08272 | - |
dc.author.google | Eunjeong Kim | en_US |
dc.author.google | Sungjun Park | en_US |
dc.author.google | Nahyun Choi | en_US |
dc.author.google | Jieon Lee | en_US |
dc.author.google | Jeehyun Yoe | en_US |
dc.author.google | Soeun Kim | en_US |
dc.author.google | Hoe-Yune Jung | en_US |
dc.author.google | Kyong-Tai Kim | en_US |
dc.author.google | Hyojin Kang | en_US |
dc.author.google | John D. Fryer | en_US |
dc.author.google | Huda Y. Zoghbi | en_US |
dc.author.google | Daehee Hwang | en_US |
dc.author.google | Yoontae Lee | en_US |
dc.relation.volume | 5 | en_US |
dc.contributor.id | 10143380 | en_US |
dc.relation.journal | Scientific Reports | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCIE | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Scientific Reports, v.5 | - |
dc.identifier.wosid | 000348833600001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.title | Scientific Reports | - |
dc.citation.volume | 5 | - |
dc.contributor.affiliatedAuthor | KIM, KYONG TAI | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.contributor.affiliatedAuthor | LEE, YOONTAE | - |
dc.identifier.scopusid | 2-s2.0-84943376843 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 8 | - |
dc.description.scptc | 10 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.description.isOpenAccess | Y | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CONSTITUTIVE ANDROSTANE RECEPTOR | - |
dc.subject.keywordPlus | ENRICHED TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | BINDING-PROTEIN-BETA | - |
dc.subject.keywordPlus | PREGNANE-X-RECEPTOR | - |
dc.subject.keywordPlus | INDUCED CHOLESTASIS | - |
dc.subject.keywordPlus | REPRESSOR CAPICUA | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | ALPHA | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.