DC Field | Value | Language |
---|---|---|
dc.contributor.author | Younghyun Kim | - |
dc.contributor.author | Goeun Lee | - |
dc.contributor.author | Eunhyun Jeon | - |
dc.contributor.author | Eun Ju Sohn | - |
dc.contributor.author | Yongjik Lee | - |
dc.contributor.author | Hyangju Kang | - |
dc.contributor.author | Dong Wook Lee | - |
dc.contributor.author | Dae Heon Kim | - |
dc.contributor.author | Hwang, I | - |
dc.date.accessioned | 2015-07-07T19:06:15Z | - |
dc.date.available | 2015-07-07T19:06:15Z | - |
dc.date.created | 2014-03-05 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.other | 2015-OAK-0000029155 | en_US |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/13093 | - |
dc.description.abstract | The nucleotide sequence around the translational initiation site is an important cis-acting element for post-transcriptional regulation. However, it has not been fully understood how the sequence context at the 5'-untranslated region (5'-UTR) affects the translational efficiency of individual mRNAs. In this study, we provide evidence that the 5'-UTRs of Arabidopsis genes showing a great difference in the nucleotide sequence vary greatly in translational efficiency with more than a 200-fold difference. Of the four types of nucleotides, the A residue was the most favourable nucleotide from positions -1 to -21 of the 5'-UTRs in Arabidopsis genes. In particular, the A residue in the 5'-UTR from positions -1 to -5 was required for a high-level translational efficiency. In contrast, the T residue in the 5'-UTR from positions -1 to -5 was the least favourable nucleotide in translational efficiency. Furthermore, the effect of the sequence context in the -1 to -21 region of the 5'-UTR was conserved in different plant species. Based on these observations, we propose that the sequence context immediately upstream of the AUG initiation codon plays a crucial role in determining the translational efficiency of plant genes. | - |
dc.description.statementofresponsibility | open | en_US |
dc.language | English | - |
dc.publisher | Oxford University Press | - |
dc.relation.isPartOf | NUCLEIC ACIDS RESEARCH | - |
dc.rights | BY_NC_ND | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/2.0/kr | en_US |
dc.subject | RNA SECONDARY STRUCTURE | - |
dc.subject | 5&apos | - |
dc.subject | UNTRANSLATED REGION | - |
dc.subject | VERTEBRATE MESSENGER-RNAS | - |
dc.subject | INITIATION CODON | - |
dc.subject | EXPRESSION | - |
dc.subject | PROTEIN | - |
dc.subject | PLANTS | - |
dc.subject | GENE | - |
dc.subject | SEQUENCES | - |
dc.subject | ELEMENT | - |
dc.title | The immediate upstream region of the 5′-UTR from the AUG start codon has a pronounced effect on the translational efficiency in Arabidopsis thaliana | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | en_US |
dc.identifier.doi | 10.1093/NAR/GKT864 | - |
dc.author.google | Kim Y., Lee G., Jeon E., Sohn E.J., Lee Y., Kang H., Lee D.W., Kim D.H., Hwang I. | en_US |
dc.relation.volume | 42 | en_US |
dc.relation.issue | 1 | en_US |
dc.relation.startpage | 485 | en_US |
dc.relation.lastpage | 498 | en_US |
dc.contributor.id | 10078446 | en_US |
dc.relation.journal | NUCLEIC ACIDS RESEARCH | en_US |
dc.relation.index | SCI급, SCOPUS 등재논문 | en_US |
dc.relation.sci | SCI | en_US |
dc.collections.name | Journal Papers | en_US |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NUCLEIC ACIDS RESEARCH, v.42, no.1, pp.485 - 498 | - |
dc.identifier.wosid | 000331136000044 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 498 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 485 | - |
dc.citation.title | NUCLEIC ACIDS RESEARCH | - |
dc.citation.volume | 42 | - |
dc.contributor.affiliatedAuthor | Eun Ju Sohn | - |
dc.contributor.affiliatedAuthor | Yongjik Lee | - |
dc.contributor.affiliatedAuthor | Hyangju Kang | - |
dc.contributor.affiliatedAuthor | Dong Wook Lee | - |
dc.contributor.affiliatedAuthor | Dae Heon Kim | - |
dc.contributor.affiliatedAuthor | Hwang, I | - |
dc.identifier.scopusid | 2-s2.0-84891797628 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 34 | - |
dc.description.scptc | 36 | * |
dc.date.scptcdate | 2018-10-274 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | RNA SECONDARY STRUCTURE | - |
dc.subject.keywordPlus | 5&apos | - |
dc.subject.keywordPlus | UNTRANSLATED REGION | - |
dc.subject.keywordPlus | VERTEBRATE MESSENGER-RNAS | - |
dc.subject.keywordPlus | INITIATION CODON | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | PLANTS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | SEQUENCES | - |
dc.subject.keywordPlus | ELEMENT | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
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