RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.
SCIE
SCOPUS
- Title
- RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.
- Authors
- Seo, M; Seo, K; Hwang, W; Koo, HJ; Hahm, JH; Yang, JS; Han, SK; Hwang, D; Kim, S; Jang, SK; Lee, Y; Nam, HG; Lee, SJV
- Date Issued
- 2015-08-04
- Publisher
- The NationalAcademy of Sciences
- Abstract
- The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan of Caenorhabditis elegans. In particular, we show that a DEAD-box RNA helicase, helicase 1 (HEL-1), promotes longevity by specifically activating the DAF-16/forkhead box O (FOXO) transcription factor signaling pathway. We find that HEL-1 is required for the longevity conferred by reduced insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) and is sufficient for extending lifespan. We further show that the expression of HEL-1 in the intestine and neurons contributes to longevity. HEL-1 enhances the induction of a large fraction of DAF-16 target genes. Thus, the RNA helicase HEL-1 appears to promote longevity in response to decreased IIS as a transcription coregulator of DAF-16. Because HEL-1 and IIS are evolutionarily well conserved, a similar mechanism for longevity regulation via an RNA helicase-dependent regulation of FOXO signaling may operate in mammals, including humans.
- Keywords
- C. elegans; aging; FOXO; insulin/IGF-1; RNA helicase; DATA INTEGRATION METHODOLOGY; C-ELEGANS; LIFE-SPAN; GENE-EXPRESSION; SYSTEMS BIOLOGY; BINDING-PROTEIN; EXPORT FACTOR; ROLES; YEAST; IDENTIFICATION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/13465
- DOI
- 10.1073/PNAS.1505451112
- ISSN
- 0027-8424
- Article Type
- Article
- Citation
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 112, no. 31, page. E4246 - E4255, 2015-08-04
- Files in This Item:
-
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.