DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shim, JH | - |
dc.contributor.author | Kim, SE | - |
dc.contributor.author | Park, JY | - |
dc.contributor.author | Kundu, J | - |
dc.contributor.author | Kim, SW | - |
dc.contributor.author | Kang, SS | - |
dc.contributor.author | Cho, DW | - |
dc.date.accessioned | 2016-03-31T07:57:28Z | - |
dc.date.available | 2016-03-31T07:57:28Z | - |
dc.date.created | 2015-01-20 | - |
dc.date.issued | 2014-07 | - |
dc.identifier.issn | 1937-3341 | - |
dc.identifier.other | 2014-OAK-0000030747 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14244 | - |
dc.description.abstract | In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery system with slow mode was successfully developed in three-dimensional (3D) printing-based polycaprolactone (PCL)/poly(lactic-co-glycolic acid) (PLGA) scaffolds for bone formation of critical-sized rabbit segmental diaphyseal defect. To control the delivery of the rhBMP-2, collagen (for long-term delivery up to 28 days) and gelatin (for shor-term delivery within a week) solutions encapsulating rhBMP-2 were dispensed into a hollow cylinderical type of PCL/PLGA scaffold. An effective dose of 5mg/mL was determined by measuring the alkaline phosphatase and osteocalcin gene expression levels of human nasal inferior turbinate-derived mesenchymal stromal cells (hTMSCs) seeded on the PCL/PLGA/collagen scaffold in vitro. However, it was found that a burst release of rhBMP-2 from the PCL/PLGA/gelatin scaffold did not induce the osteogenic differentiation of hTMSCs in vitro at an equivalent dose. In the in vivo animal experiements, microcomputed tomography and histological analyses confirmed that PCL/PLGA/collagen/rhBMP-2 scaffolds (long-term delivery mode) showed the best bone healing quality at both weeks 4 and 8 after implantation without inflammatory response. On the other hand, a large number of macrophages indicating severe inflammation provoked by burst release of rhBMP-2 were observed in the vicinity of PCL/PLGA/gelatin/rhBMP-2 (short-term delivery mode) at week 4. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | "MARY ANN LIEBERT, INC" | - |
dc.relation.isPartOf | TISSUE ENGINEERING PART A | - |
dc.subject | MESENCHYMAL STROMAL CELLS | - |
dc.subject | MORPHOGENETIC PROTEIN-2 USE | - |
dc.subject | HEAD DEPOSITION SYSTEM | - |
dc.subject | FREE-FORM FABRICATION | - |
dc.subject | OSTEOGENIC DIFFERENTIATION | - |
dc.subject | INFLAMMATORY RESPONSE | - |
dc.subject | ILIAC CREST | - |
dc.subject | IN-VIVO | - |
dc.subject | STRATEGIES | - |
dc.subject | TURBINATE | - |
dc.title | Three-Dimensional Printing of rhBMP-2-Loaded Scaffolds with Long-Term Delivery for Enhanced Bone Regeneration in a Rabbit Diaphyseal Defect | - |
dc.type | Article | - |
dc.contributor.college | 기계공학과 | - |
dc.identifier.doi | 10.1089/TEN.TEA.2013.0513 | - |
dc.author.google | Shim, JH | - |
dc.author.google | Kim, SE | - |
dc.author.google | Park, JY | - |
dc.author.google | Kundu, J | - |
dc.author.google | Kim, SW | - |
dc.author.google | Kang, SS | - |
dc.author.google | Cho, DW | - |
dc.relation.volume | 20 | - |
dc.relation.issue | 13-14 | - |
dc.relation.startpage | 1980 | - |
dc.relation.lastpage | 1992 | - |
dc.contributor.id | 10102903 | - |
dc.relation.journal | TISSUE ENGINEERING PART A | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | TISSUE ENGINEERING PART A, v.20, no.13-14, pp.1980 - 1992 | - |
dc.identifier.wosid | 000339171900020 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1992 | - |
dc.citation.number | 13-14 | - |
dc.citation.startPage | 1980 | - |
dc.citation.title | TISSUE ENGINEERING PART A | - |
dc.citation.volume | 20 | - |
dc.contributor.affiliatedAuthor | Cho, DW | - |
dc.identifier.scopusid | 2-s2.0-84904211382 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 36 | - |
dc.description.scptc | 31 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 USE | - |
dc.subject.keywordPlus | MESENCHYMAL STROMAL CELLS | - |
dc.subject.keywordPlus | FREE-FORM FABRICATION | - |
dc.subject.keywordPlus | OSTEOGENIC DIFFERENTIATION | - |
dc.subject.keywordPlus | INFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | TURBINATE | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.relation.journalWebOfScienceCategory | Cell & Tissue Engineering | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
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