Prevalence of Low Chlorinated Dibenzo-p-dioxin/Dibenzofurans in Human Serum

Abstract

Mono- to tri-chlorinated dibenzo-p-dioxin/dibenzofurans (DD/Fs) have not been studied as extensively as the 17 toxic 2,3,7,8-substituted congeners. In this study for the first time, mono- to octa-chlorinated DD/Fs were analyzed for seventy one human serum samples collected from incinerator workers as well as residents living near and far from the facility. The mean concentrations of Sigma Cl1-8DD/Fs and 17-toxic congeners were 1890 and 398 pg g(-1) lipid (11.9 TEQ pg g(-1) lipid), respectively. 2,3,4,7,8-PeCDF, 1,2,3,7,8-PeCDD, and 1,2,3,6,7,8-HxCDD were predominant congeners that accounted for more than 78% of the TEQ concentrations. The profile for polychlorinated dibenzo-p-dioxins (PCDDs) was dominated by the most chlorinated congener, OCDD (>58%), while decreasing concentrations with increasing degree of chlorination were seen for polychlorinated dibenzofurans (PCDFs); MoCDFs (>83%) and DiCDFs (>6%). Sigma CI1-3DD/Fs accounted for 77% of the serum concentrations of Sigma Cl1-8DD/Fs. These findings confirm that human beings are exposed to a large amount of ECl1-3DD/Fs. Moreover, MoCDFs contributed more than 60% of the ECl1-8DD/Fs and was highly correlated with ECl1-8DD/Fs. Thus, 2-MoCDF could be a predictive indicator for ECl(1-3)DDiFs (r s= 0.96), and the combination of 2-MoCDF and OCDD could explain the 95.9% variation in the serum of ECl1-8DD/Fs. These results suggest that low chlorinated DD/Fs should be studied extensively until these low chlorinated congeners will have been elucidated for their toxicities. (C) 2012 Elsevier Ltd. All rights reserved.