DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, GH | - |
dc.contributor.author | Park, EC | - |
dc.contributor.author | Lee, H | - |
dc.contributor.author | Na, HJ | - |
dc.contributor.author | Choi, SC | - |
dc.contributor.author | Han, JK | - |
dc.date.accessioned | 2016-03-31T08:10:25Z | - |
dc.date.available | 2016-03-31T08:10:25Z | - |
dc.date.created | 2014-03-11 | - |
dc.date.issued | 2013-05-31 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.other | 2013-OAK-0000029420 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14721 | - |
dc.description.abstract | beta-Arrestins are multifaceted proteins that play critical roles in termination of G protein-coupled receptor (GPCR) signaling by inducing its desensitization and internalization as well as in facilitation of many intracellular signaling pathways. Here, we examine using Xenopus embryos whether beta-arrestin 1 might act as a mediator of beta-catenin-independent Wnt (non-canonical) signaling. Xenopus beta-arrestin 1 (x beta arr1) is expressed in the tissues undergoing extensive cell rearrangements in early development. Gain- and loss-of-function analyses of x beta arr1 revealed that it regulates convergent extension (CE) movements of mesodermal tissue with no effect on cell fate specification. In addition, rescue experiments showed that x beta arr1 controls CE movements downstream of Wnt11/Fz7 signal and via activation of RhoA and JNK. In line with this, x beta arr1 associated with key Wnt components including Ryk, Fz, and Dishevelled. Furthermore, we found that x beta arr1 could recover CE movements inhibited by x beta arr2 knockdown or its endocytosis defective mutant. Overall, these results suggest that beta-arrestin 1 and 2 share interchangeable endocytic activity to regulate CE movements downstream of the non-canonical Wnt pathway. (c) 2013 Elsevier Inc. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.subject | beta-Arrestin 1 | - |
dc.subject | Wnt pathway | - |
dc.subject | Convergent extension movements | - |
dc.subject | Xenopus | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | XENOPUS-LAEVIS | - |
dc.subject | BETA-ARRESTIN-2 | - |
dc.subject | GASTRULATION | - |
dc.subject | ENDOCYTOSIS | - |
dc.subject | MECHANISMS | - |
dc.subject | PROTEINS | - |
dc.subject | CELLS | - |
dc.title | beta-Arrestin 1 mediates non-canonical Wnt pathway to regulate convergent extension movements | - |
dc.type | Article | - |
dc.contributor.college | 생명과학과 | - |
dc.identifier.doi | 10.1016/J.BBRC.2013.04.088 | - |
dc.author.google | Kim, GH | - |
dc.author.google | Park, EC | - |
dc.author.google | Lee, H | - |
dc.author.google | Na, HJ | - |
dc.author.google | Choi, SC | - |
dc.author.google | Han, JK | - |
dc.relation.volume | 435 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 182 | - |
dc.relation.lastpage | 187 | - |
dc.contributor.id | 10138853 | - |
dc.relation.journal | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.435, no.2, pp.182 - 187 | - |
dc.identifier.wosid | 000320828300004 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 187 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 182 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 435 | - |
dc.contributor.affiliatedAuthor | Han, JK | - |
dc.identifier.scopusid | 2-s2.0-84878467535 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 6 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | XENOPUS-LAEVIS | - |
dc.subject.keywordPlus | BETA-ARRESTIN-2 | - |
dc.subject.keywordPlus | GASTRULATION | - |
dc.subject.keywordPlus | ENDOCYTOSIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | beta-Arrestin 1 | - |
dc.subject.keywordAuthor | Wnt pathway | - |
dc.subject.keywordAuthor | Convergent extension movements | - |
dc.subject.keywordAuthor | Xenopus | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
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