DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, GHY | - |
dc.contributor.author | Stone, JC | - |
dc.contributor.author | Surh, CD | - |
dc.contributor.author | Watts, TH | - |
dc.date.accessioned | 2016-03-31T08:11:42Z | - |
dc.date.available | 2016-03-31T08:11:42Z | - |
dc.date.created | 2014-03-07 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.issn | 1440-1711 | - |
dc.identifier.other | 2012-OAK-0000029343 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/14769 | - |
dc.description.abstract | Immune complexes combining IL-2 with particular anti-IL-2 antibodies can be used to selectively expand regulatory T cells or memory T cells. Combining IL-2 with anti-IL-2 (Clone S4B6) greatly enhances the biological potency of IL-2 in vivo leading to selective expansion of CD8 memory T cells and NK cells compared with regulatory T cells. Here we show that in vivo administration of IL-2/anti-IL-2 mAb (IL-2/mAb) complexes induces 4-1BB expression on both adoptively transferred antigenspecific memory CD8 T cells as well as on endogenous memory phenotype cells. Remarkably, the accumulation of adoptively transferred memory CD8 T cells following in vivo IL-2/mAb-complex treatment was found to be dependent in part on the presence of 4-1BBL in the host. These effects were independent of IL-2-induced cell division, suggesting that 4-1BBL-induced survival signals contribute to IL-2/mAb-complex-induced T-cell accumulation in vivo. Immunology and Cell Biology (2012) 90, 743-747; doi:10.1038/icb.2011.83; published online 27 September 2011 | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | Immunology and Cell Biology | - |
dc.subject | IL-2-antibody complex | - |
dc.subject | therapy | - |
dc.subject | 4-1BBL | - |
dc.subject | CD137 | - |
dc.subject | T cell | - |
dc.subject | SELECTIVE STIMULATION | - |
dc.subject | IMMUNE-COMPLEXES | - |
dc.subject | BIM MODULATION | - |
dc.subject | IL-2 RECEPTOR | - |
dc.subject | CUTTING EDGE | - |
dc.subject | GAMMA-CHAIN | - |
dc.subject | SURVIVAL | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | COSTIMULATION | - |
dc.subject | LYMPHOCYTES | - |
dc.title | In vivo accumulation of T cells in response to IL-2/anti-IL-2 mAb complexes is dependent in part on the TNF family ligand 4-1BBL | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1038/ICB.2011.83 | - |
dc.author.google | Lin, GHY | - |
dc.author.google | Stone, JC | - |
dc.author.google | Surh, CD | - |
dc.author.google | Watts, TH | - |
dc.relation.volume | 90 | - |
dc.relation.issue | 7 | - |
dc.relation.startpage | 743 | - |
dc.relation.lastpage | 747 | - |
dc.contributor.id | 10201353 | - |
dc.relation.journal | Immunology and Cell Biology | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Immunology and Cell Biology, v.90, no.7, pp.743 - 747 | - |
dc.identifier.wosid | 000307611700010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 747 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 743 | - |
dc.citation.title | Immunology and Cell Biology | - |
dc.citation.volume | 90 | - |
dc.contributor.affiliatedAuthor | Surh, CD | - |
dc.identifier.scopusid | 2-s2.0-84864837836 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 4 | - |
dc.description.scptc | 5 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | SELECTIVE STIMULATION | - |
dc.subject.keywordPlus | BIM MODULATION | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | GAMMA-CHAIN | - |
dc.subject.keywordPlus | IL-2 | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | COSTIMULATION | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordAuthor | IL-2-antibody complex | - |
dc.subject.keywordAuthor | therapy | - |
dc.subject.keywordAuthor | 4-1BBL | - |
dc.subject.keywordAuthor | CD137 | - |
dc.subject.keywordAuthor | T cell | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalResearchArea | Immunology | - |
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