DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, SY | - |
dc.contributor.author | Chung, YS | - |
dc.contributor.author | Choi, B | - |
dc.contributor.author | Kim, M | - |
dc.contributor.author | Kim, JH | - |
dc.contributor.author | Jun, TG | - |
dc.contributor.author | Chang, J | - |
dc.contributor.author | Sprent, J | - |
dc.contributor.author | Surh, CD | - |
dc.contributor.author | Joh, JW | - |
dc.contributor.author | Kim, SJ | - |
dc.date.accessioned | 2016-03-31T08:22:51Z | - |
dc.date.available | 2016-03-31T08:22:51Z | - |
dc.date.created | 2013-12-19 | - |
dc.date.issued | 2012-12-15 | - |
dc.identifier.issn | 0041-1337 | - |
dc.identifier.other | 2012-OAK-0000028480 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15175 | - |
dc.description.abstract | Background. In many humanized mouse models, there are few T cells in the engrafted human cell, whereas the number of B cells is high. We attempted to overcome this limitation and investigate whether the entire process of human T cell development arose similarly to the process in humans, as previously reported. Methods. To produce an advanced humanized mice model, we transplanted human fetal liver/thymus tissue sub-renally and injected human CD34(+) stem cells intravenously into NOD/SCID/IL2Rgamma null (NSG) mice. Results. Humanized mice transplanted with fetal thymus/liver tissues and fetal liver-derived CD34(+) stem cells (FLT+ FLCD34) showed higher levels of human cells and T cells than mice transplanted with fetal liver-derived CD34(+) stem cells only (FLCD34). In the transplanted thymus tissue of FLT+ FLCD34 mice, thymus seeding progenitors (TSPs), early thymic progenitors (ETPs), pre-T cells, and all the other human T cell populations were identified. In the periphery, FLT+FLCD34 mice have high levels of CD45RA(+) T cells; conversely, FLCD34 mice have higher levels of CD45RO(+) T cells. The CD45RO(+) T cells of FLCD34 mice proliferated rapidly after stimulation and exhibited innate T cells properties, expressing PLZF (promyelocytic leukemia zinc finger protein). Conclusion. Human T cells educated by mouse MHC II in mice without a human thymus differ from normal human T cells. On the basis of these findings, numerous T cell-tropic human diseases could be explored in our humanized mice and molecular aspects of human T cell development could be also studied extensively. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | Transplantation | - |
dc.subject | Human T cell development | - |
dc.subject | Fetal thymus/liver | - |
dc.subject | NOD/SCID/IL2Rgamma null mice | - |
dc.subject | Innate T cell | - |
dc.subject | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | MODEL | - |
dc.subject | TRANSPLANTATION | - |
dc.subject | EXPRESSION | - |
dc.subject | EFFECTOR | - |
dc.subject | MOUSE | - |
dc.subject | BLOOD | - |
dc.title | Systemic human T cell developmental processes in humanized mice cotransplanted with human fetal thymus/liver tissue and hematopoietic stem cells | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1097/TP.0B013E318270F392 | - |
dc.author.google | Joo, SY | - |
dc.author.google | Chung, YS | - |
dc.author.google | Choi, B | - |
dc.author.google | Kim, M | - |
dc.author.google | Kim, JH | - |
dc.author.google | Jun, TG | - |
dc.author.google | Chang, J | - |
dc.author.google | Sprent, J | - |
dc.author.google | Surh, CD | - |
dc.author.google | Joh, JW | - |
dc.author.google | Kim, SJ | - |
dc.relation.volume | 94 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 1059 | - |
dc.relation.lastpage | 1102 | - |
dc.contributor.id | 10201353 | - |
dc.relation.journal | Transplantation | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCIE | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Transplantation, v.94, no.11, pp.1059 - 1102 | - |
dc.identifier.wosid | 000312072600010 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1102 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1059 | - |
dc.citation.title | Transplantation | - |
dc.citation.volume | 94 | - |
dc.contributor.affiliatedAuthor | Surh, CD | - |
dc.identifier.scopusid | 2-s2.0-84871531019 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 10 | - |
dc.description.scptc | 9 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | THYMOCYTE-THYMOCYTE INTERACTION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | EFFECTOR | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | BLOOD | - |
dc.subject.keywordAuthor | Human T cell development | - |
dc.subject.keywordAuthor | Fetal thymus/liver | - |
dc.subject.keywordAuthor | NOD/SCID/IL2Rgamma null mice | - |
dc.subject.keywordAuthor | Innate T cell | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.relation.journalWebOfScienceCategory | Transplantation | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalResearchArea | Transplantation | - |
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