DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, E | - |
dc.contributor.author | Kamlet, AS | - |
dc.contributor.author | Powers, DC | - |
dc.contributor.author | Neumann, CN | - |
dc.contributor.author | Boursalian, GB | - |
dc.contributor.author | Furuya, T | - |
dc.contributor.author | Choi, DC | - |
dc.contributor.author | Hooker, JM | - |
dc.contributor.author | Ritter, T | - |
dc.date.accessioned | 2016-03-31T08:23:10Z | - |
dc.date.available | 2016-03-31T08:23:10Z | - |
dc.date.created | 2013-12-19 | - |
dc.date.issued | 2011-11-04 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.other | 2011-OAK-0000028465 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15187 | - |
dc.description.abstract | The unnatural isotope fluorine-18 (F-18) is used as a positron emitter in molecular imaging. Currently, many potentially useful F-18-labeled probe molecules are inaccessible for imaging because no fluorination chemistry is available to make them. The 110-minute half-life of F-18 requires rapid syntheses for which [F-18]fluoride is the preferred source of fluorine because of its practical access and suitable isotope enrichment. However, conventional [F-18]fluoride chemistry has been limited to nucleophilic fluorination reactions. We report the development of a palladium-based electrophilic fluorination reagent derived from fluoride and its application to the synthesis of aromatic F-18-labeled molecules via late-stage fluorination. Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isPartOf | SCIENCE | - |
dc.subject | POSITRON-EMISSION-TOMOGRAPHY | - |
dc.subject | REDUCTIVE ELIMINATION | - |
dc.subject | RADIOSYNTHESIS | - |
dc.subject | F-18 | - |
dc.title | A Fluoride-derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1126/SCIENCE.1212625 | - |
dc.author.google | Lee, E | - |
dc.author.google | Kamlet, AS | - |
dc.author.google | Powers, DC | - |
dc.author.google | Neumann, CN | - |
dc.author.google | Boursalian, GB | - |
dc.author.google | Furuya, T | - |
dc.author.google | Choi, DC | - |
dc.author.google | Hooker, JM | - |
dc.author.google | Ritter, T | - |
dc.relation.volume | 334 | - |
dc.relation.issue | 6056 | - |
dc.relation.startpage | 639 | - |
dc.relation.lastpage | 642 | - |
dc.contributor.id | 10145005 | - |
dc.relation.journal | SCIENCE | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | SCIENCE, v.334, no.6056, pp.639 - 642 | - |
dc.identifier.wosid | 000296494700046 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 642 | - |
dc.citation.number | 6056 | - |
dc.citation.startPage | 639 | - |
dc.citation.title | SCIENCE | - |
dc.citation.volume | 334 | - |
dc.contributor.affiliatedAuthor | Lee, E | - |
dc.identifier.scopusid | 2-s2.0-80555125102 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 225 | - |
dc.description.scptc | 220 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | REDUCTIVE ELIMINATION | - |
dc.subject.keywordPlus | RADIOSYNTHESIS | - |
dc.subject.keywordPlus | F-18 | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
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