DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Namgung, R | - |
dc.contributor.author | Kim, WJ | - |
dc.contributor.author | Kim, JI | - |
dc.contributor.author | Park, IK | - |
dc.date.accessioned | 2016-03-31T08:23:29Z | - |
dc.date.available | 2016-03-31T08:23:29Z | - |
dc.date.created | 2013-12-19 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.other | 2013-OAK-0000028444 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15199 | - |
dc.description.abstract | Development of a targeted polymeric gene delivery system is essential for reducing the non-specific uptake and toxicity of the gene carriers. In this study, we have tested the specificity of the cell penetrating peptide (DS 4-3), screened by phage display technique, towards metastatic breast cancer cells. This peptide has shown specificity towards metastatic breast cancer cells, which was confirmed through endocytosis inhibition study. Furthermore, the DS 4-3 peptide was conjugated to bPEI, to deliver the therapeutic miR-145. Tumor suppressor miR-145 inhibited tumor cell growth, and significantly suppressed cell invasion. The DS 4-3 peptide conjugated branched PEI (DSbPEI)/pLuc nanoparticles showed increased transfection in malignant murine breast cancer cells at the neutral surface charge (N/P molar ratio of 3), compared to scramble peptide conjugated bPEI/pLuc nanoparticles, without causing any cytotoxicity. This specific increase in transfection with DS-bPEI/pLuc nanoparticles was not found in the cancer cells that originated from different tissue, such as HeLa cervical cancer cells, or in the normal cells, such as NIH-3T3 murine fibroblast cells. Thus, the specific transfection of miR-145 in metastatic breast cancer cells mediated by DS-bPEI resulted in enhanced reduction in proliferation. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | POLYMER SOC KOREA | - |
dc.relation.isPartOf | MACROMOLECULAR RESEARCH | - |
dc.subject | cell-penetrating peptides | - |
dc.subject | tissue targeting | - |
dc.subject | gene delivery | - |
dc.subject | metastatic breast cancer | - |
dc.subject | microRNA-145 | - |
dc.subject | CELL-PENETRATING PEPTIDES | - |
dc.subject | IN-VITRO | - |
dc.subject | THERAPY | - |
dc.subject | SUPPRESSES | - |
dc.subject | EXPRESSION | - |
dc.subject | RESISTANCE | - |
dc.subject | MECHANISM | - |
dc.subject | INVASION | - |
dc.subject | RECEPTOR | - |
dc.subject | MODEL | - |
dc.title | Targeted delivery of microRNA-145 to metastatic breast cancer by peptide conjugated branched PEI gene carrier | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1007/S13233-013-1161-Z | - |
dc.author.google | Lee, HJ | - |
dc.author.google | Namgung, R | - |
dc.author.google | Kim, WJ | - |
dc.author.google | Kim, JI | - |
dc.author.google | Park, IK | - |
dc.relation.volume | 21 | - |
dc.relation.issue | 11 | - |
dc.relation.startpage | 1201 | - |
dc.relation.lastpage | 1209 | - |
dc.contributor.id | 10135304 | - |
dc.relation.journal | MACROMOLECULAR RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | MACROMOLECULAR RESEARCH, v.21, no.11, pp.1201 - 1209 | - |
dc.identifier.wosid | 000322737700007 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 1209 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1201 | - |
dc.citation.title | MACROMOLECULAR RESEARCH | - |
dc.citation.volume | 21 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.identifier.scopusid | 2-s2.0-84881477093 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 9 | - |
dc.description.scptc | 9 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | CELL-PENETRATING PEPTIDES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | SUPPRESSES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | RESISTANCE | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | cell-penetrating peptides | - |
dc.subject.keywordAuthor | tissue targeting | - |
dc.subject.keywordAuthor | gene delivery | - |
dc.subject.keywordAuthor | metastatic breast cancer | - |
dc.subject.keywordAuthor | microRNA-145 | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Polymer Science | - |
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