DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lovell, JF | - |
dc.contributor.author | Jin, CS | - |
dc.contributor.author | Huynh, E | - |
dc.contributor.author | Jin, HL | - |
dc.contributor.author | Kim, C | - |
dc.contributor.author | Rubinstein, JL | - |
dc.contributor.author | Chan, WCW | - |
dc.contributor.author | Cao, WG | - |
dc.contributor.author | Wang, LV | - |
dc.contributor.author | Zheng, G | - |
dc.date.accessioned | 2016-03-31T08:29:10Z | - |
dc.date.available | 2016-03-31T08:29:10Z | - |
dc.date.created | 2013-07-31 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.issn | 1476-1122 | - |
dc.identifier.other | 2011-OAK-0000027893 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/15413 | - |
dc.description.abstract | Optically active nanomaterials promise to advance a range of biophotonic techniques through nanoscale optical effects and integration of multiple imaging and therapeutic modalities. Here, we report the development of porphysomes; nanovesicles formed from self-assembled porphyrin bilayers that generated large, tunable extinction coefficients, structure-dependent fluorescence self-quenching and unique photothermal and photoacoustic properties. Porphysomes enabled the sensitive visualization of lymphatic systems using photoacoustic tomography. Near-infrared fluorescence generation could be restored on dissociation, creating opportunities for low-background fluorescence imaging. As a result of their organic nature, porphysomes were enzymatically biodegradable and induced minimal acute toxicity in mice with intravenous doses of 1,000 mg kg(-1). In a similar manner to liposomes, the large aqueous core of porphysomes could be passively or actively loaded. Following systemic administration, porphysomes accumulated in tumours of xenograft-bearing mice and laser irradiation induced photothermal tumour ablation. The optical properties and biocompatibility of porphysomes demonstrate the multimodal potential of organic nanoparticles for biophotonic imaging and therapy. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NATURE MATERIALS | - |
dc.subject | CANCER-THERAPY | - |
dc.subject | PHOTOACOUSTIC DETECTION | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | PHOTOTHERMAL THERAPY | - |
dc.subject | LIGHT-SCATTERING | - |
dc.subject | TUMOR | - |
dc.subject | NANOPARTICLES | - |
dc.subject | LIPOSOMES | - |
dc.subject | POLYMERSOMES | - |
dc.subject | TOMOGRAPHY | - |
dc.title | Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents | - |
dc.type | Article | - |
dc.contributor.college | 전자전기공학과 | - |
dc.identifier.doi | 10.1038/NMAT2986 | - |
dc.author.google | Lovell, JF | - |
dc.author.google | Jin, CS | - |
dc.author.google | Huynh, E | - |
dc.author.google | Jin, HL | - |
dc.author.google | Kim, C | - |
dc.author.google | Rubinstein, JL | - |
dc.author.google | Chan, WCW | - |
dc.author.google | Cao, WG | - |
dc.author.google | Wang, LV | - |
dc.author.google | Zheng, G | - |
dc.relation.volume | 10 | - |
dc.relation.issue | 4 | - |
dc.relation.startpage | 324 | - |
dc.relation.lastpage | 332 | - |
dc.contributor.id | 11117022 | - |
dc.relation.journal | NATURE MATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | NATURE MATERIALS, v.10, no.4, pp.324 - 332 | - |
dc.identifier.wosid | 000288744700024 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 332 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 324 | - |
dc.citation.title | NATURE MATERIALS | - |
dc.citation.volume | 10 | - |
dc.contributor.affiliatedAuthor | Kim, C | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 584 | - |
dc.type.docType | Article | - |
dc.subject.keywordPlus | PHOTOACOUSTIC DETECTION | - |
dc.subject.keywordPlus | LIGHT-SCATTERING | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | LIPOSOMES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | POLYMERSOMES | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | EFFICIENT | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
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