Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography
SCIE
SCOPUS
- Title
- Multimodal sentinel lymph node mapping with single-photon emission computed tomography (SPECT)/computed tomography (CT) and photoacoustic tomography
- Authors
- Akers, WJ; Edwards, WB; Kim, C; Xu, BG; Erpelding, TN; Wang, LHV; Achilefu, S
- Date Issued
- 2012-03
- Publisher
- ELSEVIER
- Abstract
- The identification of cancer cells in the lymph nodes surrounding a tumor is important in establishing a prognosis. Optical detection techniques such as fluorescence and photoacoustic tomography (PAT) have been reported in preclinical studies for noninvasive sentinel lymph node (SLN) mapping. A method for validation of these techniques is needed for clinical trials. We report the use of a multimodal opticalradionuclear contrast agent as a validation tool for PAT in a preclinical model. Methylene blue (MB) was radiolabeled with I-125 for multimodal SLN mapping and used in conjunction with MB to assess the feasibility of multimodal SIN mapping in a rat model by PAT and single-photon emission computed tomography (SPEC). MB provided sufficient contrast for identifying SLNs noninvasively with a PAT system adapted from a clinical ultrasound imaging system. The signal location was corroborated by SPECT using I-125 labeled MB. The translation of PAT into the clinic can be facilitated by a direct comparison with established imaging methods using a clinically relevant dual SPECT and photoacoustic imaging agent. The new high-resolution PAT is a promising technology for the sensitive and accurate SIN detection in cancer patients. (Translational Research 2012;159:175-181)
- Keywords
- METHYLENE-BLUE; BREAST-CANCER; MELANOMA; RADIOISOTOPE; DYE; DRAINAGE; BIOPSY; TRIAL
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15417
- DOI
- 10.1016/j.trsl.2011.09.006
- ISSN
- 1931-5244
- Article Type
- Article
- Citation
- TRANSLATIONAL RESEARCH, vol. 159, no. 3, page. 175 - 181, 2012-03
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