Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties
SCIE
SCOPUS
- Title
- Porphyrin Shell Microbubbles with Intrinsic Ultrasound and Photoacoustic Properties
- Authors
- Huynh, E; Lovell, JF; Helfield, BL; Jeon, M; Kim, C; Goertz, DE; Wilson, BC; Zheng, G
- Date Issued
- 2012-10-10
- Publisher
- ACS Publications
- Abstract
- Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 +/- 0.2 mu m. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.
- Keywords
- CONTRAST AGENTS; SIZE DISTRIBUTION; IN-VIVO; PORPHYSOME NANOVESICLES; DESTRUCTION; VAPORIZATION; DELIVERY; SYSTEM; TISSUE; GENE
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15418
- DOI
- 10.1021/ja305988f
- ISSN
- 0002-7863
- Article Type
- Article
- Citation
- JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 134, no. 40, page. 16464 - 16467, 2012-10-10
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- There are no files associated with this item.
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