In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes
SCIE
SCOPUS
- Title
- In vivo non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes
- Authors
- Koo, J; Jeon, M; Oh, Y; Kang, HW; Kim, J; Kim, C; Oh, J
- Date Issued
- 2012-12-07
- Publisher
- IOP Publishing
- Abstract
- We demonstrate the feasibility of mapping a sentinel lymph node (SLN) and urinary bladder by using modified single-walled carbon nanotubes (SWNTs) as a nonionizing photoacoustic (PA) contrast agent. To improve the PA sensitivity, indocyanine green (ICG) was conjugated with SWNTs and the optical absorption of SWNTs-ICG was enhanced by approximately four times compared to that of plain SWNTs at a concentration of 0.3 mu M. In vivo PA imaging results showed that the SLN and bladder were clearly visualized due to accumulation of SWNTs-ICG. This implies that the SWNTs-ICG could be potentially utilized to identify SLNs in breast cancer patients and tracking vesicoureteral reflux in combination with PA imaging.
- Keywords
- CONTRAST AGENTS; GOLD NANOCAGES; BREAST-CANCER; INDOCYANINE GREEN; ULTRASOUND ARRAY; HIGH-RESOLUTION; MICE; TOMOGRAPHY; SYSTEM; BIODISTRIBUTION
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/15420
- DOI
- 10.1088/0031-9155/57/23/7853
- ISSN
- 0031-9155
- Article Type
- Article
- Citation
- PHYSICS IN MEDICINE AND BIOLOGY, vol. 57, no. 23, page. 7853 - 7862, 2012-12-07
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- There are no files associated with this item.
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