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Cited 33 time in webofscience Cited 21 time in scopus
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dc.contributor.authorJinkyung Kim-
dc.contributor.authorYoon Ha Choi-
dc.contributor.authorSoeun Chang-
dc.contributor.authorKim, KT-
dc.contributor.authorJe, JH-
dc.date.accessioned2016-03-31T08:54:55Z-
dc.date.available2016-03-31T08:54:55Z-
dc.date.created2012-11-22-
dc.date.issued2012-06-25-
dc.identifier.issn2045-2322-
dc.identifier.other2012-OAK-0000025994-
dc.identifier.urihttps://oasis.postech.ac.kr/handle/2014.oak/16296-
dc.description.abstractThe Vaccinia-related kinase 1(VRK1), which is generally implicated in modulating cell cycle, plays important roles in mammalian gametogenesis. Female infertility in VRK1-deficient mice was reported to be caused by defective meiotic progression in oocyte at postovulatory stage. VRK1 roles in folliculogenesis, however, remain largely unknown. Here, accurate quantification of folliculogenesis is performed by a direct visualization of 'intact' ovary in 3-dimensions (3-D) using a synchrotron X-ray microtomography. In VRK1-deficient ovaries, the numbers of pre-antral and antral follicles are significantly reduced by 38% and 46%, respectively, comparing to control. The oocytes volumes in antral and Graffian follicles also decrease by 42% and 37% in the mutants, respectively, indicating defects in oocyte quality at preovulatory stage. Genetic analysis shows that gene expressions related to folliculogenesis are down-regulated in VRK1-deficient ovaries, implying defects in folliculogenesis. We suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.-
dc.description.statementofresponsibilityX-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.titleDefective folliculogenesis in female mice lacking Vaccinia-related kinase 1-
dc.typeArticle-
dc.contributor.college신소재공학과-
dc.identifier.doi10.1038/SREP00468-
dc.author.googleKim, J-
dc.author.googleChoi, YH-
dc.author.googleChang, S-
dc.author.googleKim, KT-
dc.author.googleJe, JH-
dc.relation.volume2-
dc.contributor.id10123980-
dc.relation.journalSCIENTIFIC REPORTS-
dc.relation.indexSCI급, SCOPUS 등재논문-
dc.relation.sciSCI-
dc.collections.nameJournal Papers-
dc.type.rimsART-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.2-
dc.identifier.wosid000306005900001-
dc.date.tcdate2019-01-01-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume2-
dc.contributor.affiliatedAuthorKim, KT-
dc.contributor.affiliatedAuthorJe, JH-
dc.identifier.scopusid2-s2.0-84871865507-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.wostc18-
dc.description.scptc11*
dc.date.scptcdate2018-05-121*
dc.type.docTypeArticle-
dc.subject.keywordPlusFOLLICLE-STIMULATING-HORMONE-
dc.subject.keywordPlusGROWTH-DIFFERENTIATION FACTOR-9-
dc.subject.keywordPlusANTI-MULLERIAN HORMONE-
dc.subject.keywordPlusOVARIAN-FOLLICLE-
dc.subject.keywordPlusOOCYTE DIAMETER-
dc.subject.keywordPlusRECEPTOR GENE-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusCOMPETENCE-
dc.subject.keywordPlusVRK1-
dc.subject.keywordPlusQUANTIFICATION-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-

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김경태KIM, KYONG TAI
Dept of Life Sciences
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