Mass-producible nano-featured polystyrene surfaces for regulating the differentiation of human adipose-derived stem cells
SCIE
SCOPUS
- Title
- Mass-producible nano-featured polystyrene surfaces for regulating the differentiation of human adipose-derived stem cells
- Authors
- Park, KS; Kyoung Je Cha; In-Bo Han; Dong-Ah Shin; Dong-Woo Cho; Soo-Hong Lee; Kim, DS
- Date Issued
- 2012-11
- Publisher
- WILEY online publish
- Abstract
- In this study, we report an efficient and cost-effective method of fabricating polystyrene (PS) nano-featured substrates containing nanopore (NPo) and nanopillar (NPi) arrays based on hot embossing using nickel nano-stamps. We investigate the behavior of adipose-derived stem cells (ASCs), including adhesion, morphology, proliferation and differentiation, on the replicated PS surfaces. Compared to a flat substrate, NPo- and NPi-featured substrates do not alter the morphology of stem cells. However, both NPo- and NPi-featured substrates induce different integrin expression and lower formation of focal adhesion complexes. In addition, ASCs on the NPo-featured substrate exhibit greater adipogenic differentiation, while the NPi-featured substrate induces higher osteogenic differentiation.
- URI
- https://oasis.postech.ac.kr/handle/2014.oak/16304
- DOI
- 10.1002/MABI.201200225
- ISSN
- 1616-5187
- Article Type
- Article
- Citation
- Macromolecular Bioscience, vol. 12, no. 11, page. 1480 - 1489, 2012-11
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