DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, JH | - |
dc.contributor.author | Lee, CS | - |
dc.contributor.author | Hwang, D | - |
dc.contributor.author | Ryu, SH | - |
dc.date.accessioned | 2016-03-31T08:56:59Z | - |
dc.date.available | 2016-03-31T08:56:59Z | - |
dc.date.created | 2012-08-09 | - |
dc.date.issued | 2012-04 | - |
dc.identifier.issn | 0163-7827 | - |
dc.identifier.other | 2012-OAK-0000025782 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16359 | - |
dc.description.abstract | Phospholipase D (PLD) is a phosphatidyl choline (PC)-hydrolyzing enzyme that generates phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling. Through interactions with signaling molecules, both PLD and PA can mediate a variety of cellular functions, such as, growth/proliferation, vesicle trafficking, cytoskeleton modulation, development, and morphogenesis. Therefore, systemic approaches for investigating PLO networks including interrelationship between PLD and PA and theirs binding partners, such as proteins and lipids, can enhance fundamental knowledge of roles of PLD and PA in diverse biological processes. In this review, we summarize previously reported protein-protein and protein-lipid interactions of PLD and PA and their binding partners. In addition, we describe the functional roles played by PLD and PA in these interactions, and provide PLO network that summarizes these interactions. The PLD network suggests that PLO and PA could act as a decision maker and/or as a coordinator of signal dynamics. This viewpoint provides a turning point for understanding the roles of PLD-PA as a dynamic signaling hub. (C) 2011 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | ELSEVIER | - |
dc.relation.isPartOf | PROGRESS IN LIPID RESEARCH | - |
dc.subject | Phospholipase D | - |
dc.subject | Phosphatidic acid | - |
dc.subject | Binding partners | - |
dc.subject | Interaction network | - |
dc.subject | Signaling dynamics | - |
dc.subject | Network motif | - |
dc.subject | PROTEIN-KINASE-C | - |
dc.subject | ADP-RIBOSYLATION FACTOR | - |
dc.subject | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | - |
dc.subject | CAMP-SPECIFIC PHOSPHODIESTERASE | - |
dc.subject | PHEOCHROMOCYTOMA PC12 CELLS | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | D ACTIVATION | - |
dc.subject | NETWORK MOTIFS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.title | Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners | - |
dc.type | Article | - |
dc.contributor.college | 융합생명공학부 | - |
dc.identifier.doi | 10.1016/j.plipres.2011.12.003 | - |
dc.author.google | Jang, JH | - |
dc.author.google | Lee, CS | - |
dc.author.google | Hwang, D | - |
dc.author.google | Ryu, SH | - |
dc.relation.volume | 51 | - |
dc.relation.issue | 2 | - |
dc.relation.startpage | 71 | - |
dc.relation.lastpage | 81 | - |
dc.contributor.id | 10180943 | - |
dc.relation.journal | PROGRESS IN LIPID RESEARCH | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | PROGRESS IN LIPID RESEARCH, v.51, no.2, pp.71 - 81 | - |
dc.identifier.wosid | 000301813000001 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 81 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 71 | - |
dc.citation.title | PROGRESS IN LIPID RESEARCH | - |
dc.citation.volume | 51 | - |
dc.contributor.affiliatedAuthor | Hwang, D | - |
dc.contributor.affiliatedAuthor | Ryu, SH | - |
dc.identifier.scopusid | 2-s2.0-84862815824 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 60 | - |
dc.type.docType | Review | - |
dc.subject.keywordPlus | PROTEIN-KINASE-C | - |
dc.subject.keywordPlus | ADP-RIBOSYLATION FACTOR | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | - |
dc.subject.keywordPlus | CAMP-SPECIFIC PHOSPHODIESTERASE | - |
dc.subject.keywordPlus | PHEOCHROMOCYTOMA PC12 CELLS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | D ACTIVATION | - |
dc.subject.keywordPlus | NETWORK MOTIFS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordAuthor | Phospholipase D | - |
dc.subject.keywordAuthor | Phosphatidic acid | - |
dc.subject.keywordAuthor | Binding partners | - |
dc.subject.keywordAuthor | Interaction network | - |
dc.subject.keywordAuthor | Signaling dynamics | - |
dc.subject.keywordAuthor | Network motif | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
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