DC Field | Value | Language |
---|---|---|
dc.contributor.author | Min, K | - |
dc.contributor.author | Jo, H | - |
dc.contributor.author | Song, K | - |
dc.contributor.author | Cho, M | - |
dc.contributor.author | Chun, YS | - |
dc.contributor.author | Jon, S | - |
dc.contributor.author | Kim, WJ | - |
dc.contributor.author | BAN, CHANGILL | - |
dc.date.accessioned | 2016-03-31T09:11:55Z | - |
dc.date.available | 2016-03-31T09:11:55Z | - |
dc.date.created | 2011-03-07 | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.other | 2011-OAK-0000024836 | - |
dc.identifier.uri | https://oasis.postech.ac.kr/handle/2014.oak/16804 | - |
dc.description.abstract | We have designed a dual-aptamer complex specific to both prostate-specific membrane antigens (PSMA) (+) and (-) prostate cancer cells. In the complex, an A10 RNA aptamer targeting PSMA (+) cells and a DUP-1 peptide aptamer specific to PSMA (-) cells were conjugated through streptavidin. Doxorubicin-loaded onto the stem region of the A10 aptamer was delivered not only to PSMA (+) cells but to PSMA (-) cells, and eventually induced apoptosis in both types of prostate cancer cells. Cell death was monitored by measuring guanine concentration in cells using differential pulse voltammetry (DPV), a simple and rapid electrochemical method, and was further confirmed by directly observing cell morphologies cultured on the transparent indium tin oxide (ITO) glass electrode and checking their viabilities using a trypan blue assay. To investigate the in vivo application of the dual-aptamer system, both A10 and DUP-1 aptamers were immobilized on the surface of thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION). Selective cell uptakes and effective drug delivery action of these probes were verified by Prussian blue staining and trypan blue staining, respectively. (C) 2010 Elsevier Ltd. All rights reserved. | - |
dc.description.statementofresponsibility | X | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Biomaterials | - |
dc.title | Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (−) prostate cancers | - |
dc.type | Article | - |
dc.contributor.college | 화학과 | - |
dc.identifier.doi | 10.1016/J.BIOMATERIALS.2010.11.035 | - |
dc.author.google | Min, K | - |
dc.author.google | Jo, H | - |
dc.author.google | Song, K | - |
dc.author.google | Cho, M | - |
dc.author.google | Chun, YS | - |
dc.author.google | Jon, S | - |
dc.author.google | Kim, WJ | - |
dc.author.google | Ban, C | - |
dc.relation.volume | 32 | - |
dc.relation.issue | 8 | - |
dc.relation.startpage | 2124 | - |
dc.relation.lastpage | 2132 | - |
dc.contributor.id | 10135304 | - |
dc.relation.journal | BIOMATERIALS | - |
dc.relation.index | SCI급, SCOPUS 등재논문 | - |
dc.relation.sci | SCI | - |
dc.collections.name | Journal Papers | - |
dc.type.rims | ART | - |
dc.identifier.bibliographicCitation | Biomaterials, v.32, no.8, pp.2124 - 2132 | - |
dc.identifier.wosid | 000287061400013 | - |
dc.date.tcdate | 2019-01-01 | - |
dc.citation.endPage | 2132 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2124 | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 32 | - |
dc.contributor.affiliatedAuthor | Kim, WJ | - |
dc.contributor.affiliatedAuthor | BAN, CHANGILL | - |
dc.identifier.scopusid | 2-s2.0-78651419151 | - |
dc.description.journalClass | 1 | - |
dc.description.journalClass | 1 | - |
dc.description.wostc | 84 | - |
dc.description.scptc | 85 | * |
dc.date.scptcdate | 2018-05-121 | * |
dc.type.docType | Article | - |
dc.subject.keywordPlus | IRON-OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | TARGETED DRUG-DELIVERY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | MEMBRANE ANTIGEN | - |
dc.subject.keywordPlus | ELECTROCHEMICAL DETECTION | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | NUCLEIC-ACIDS | - |
dc.subject.keywordPlus | DNA SENSORS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | Drug delivery | - |
dc.subject.keywordAuthor | PSMA (+) and PSMA (-) prostate cancer cells | - |
dc.subject.keywordAuthor | A10 RNA aptamer | - |
dc.subject.keywordAuthor | DUP-1 peptide aptamer | - |
dc.subject.keywordAuthor | Differential pulse voltammetry | - |
dc.subject.keywordAuthor | Superparamagnetic iron oxide nanoparticle | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
library@postech.ac.kr Tel: 054-279-2548
Copyrights © by 2017 Pohang University of Science ad Technology All right reserved.